Although (3-human papillomaviruses ((3-HPVs) have been proposed to driv< the initiation of skin cancer, previous studies have failed to establish any causative link. Now, a recent study in Nature from the group of Shadmehr Demehri suggests that commensal (3-HPVs actually enhance the antitumour functions of CD8+ T cells in the skin against cancer.There are approximately 200 different HPV types, including the low-risk a-HPVs that induce warts and the high-risk a-HPVs that can promote the development of cervical and other cancers. (3-HPVs are detected in more than 80% of squamous cell carcinomas (SCCs) that develop in transplant patients, and these viruses have therefore been associated with skin cancer. However, no predominant (3-HPV types have been identified in skin cancer and the (3-HPV genome is rarely integrated into the DNA of skin cancer cells. This has led to the development of the 'hit and run' hypothesis, which proposes that P-HPV facilitates the initial development of UV radiation (UVR)-driven skin cancer but is not required for cancer progression.
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