Composite Nanoparticles Based on the Lexan Polymer Matrix, Ytterbium Complexes of Porphyrins, and Iron Oxide for NIR Luminescent Diagnostics and Neoplasm Theranostics

摘要

The synthesis procedure and the spectral luminescent properties of nanoparticles containing the ytterbium complex of protoporphyrin IX dimethyl ester in a Lexan-based polymer matrix, promising for application in neoplasm diagnostics, are described. Nanoparticles have an increased luminescence lifetime in the 700-1100 nm near infrared region and almost no porphyrin free base fluorescence in the red spectral region, which shows promise in using the nanoparticles for diagnostic purposes. For theranostic purposes, the synthesis of multifunctional nanoparticles with a core of iron oxides and a Lexan-polymer shell containing the ytterbium complex of hematoporphyrin IX tetramethyl ester was carried out. We assume iron oxide nanoparticles are responsible for the local hyperthermia procedure.