Magnetic Nanostructured System for Biomedical Applications Based on FeNi Nanotubes

摘要

FeNi nanotubes with a length of 12 μm, a diameter of 400 nm, and a wall thickness of ~120 nm (obtained by template synthesis in the pores of polyethylene terephthalate ion-track membranes) are used to create a tool for the targeted delivery of drugs and genes. The possibility of coating their surface with a biocompatible polymer (polymethylmethacrylate) and the functionalization by the protein on the example of concanavalin A as a magnetic carrier for targeted delivery is demonstrated. To implement the system for the targeted delivery of drugs such as “magnetic nanostructure + polymer coating + pharmaceutical agent” based on FeNi nanotubes, a scheme for the phased functionalization of nanostructures is developed which includes three main stages: (1) passivation of the surface with the formation of OH groups on the surface of nanotubes through which (2) polymethylmethacrylate molecules are attached through carboxyl groups and (3) concanavalin A molecules are immobilized on the surface of the polymer film through amide groups.