...
首页> 外文期刊>BJU international >Usefulness of the 2005 International Society of Urologic Pathology Gleason grading system in prostate biopsy and radical prostatectomy specimens.
【24h】

Usefulness of the 2005 International Society of Urologic Pathology Gleason grading system in prostate biopsy and radical prostatectomy specimens.

机译:2005年国际泌尿外科病理学会Gleason评分系统在前列腺活检和根治性前列腺切除术标本中的作用。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

OBJECTIVE: To determine whether the 2005 International Society of Urologic Pathology (ISUP) Gleason Grading Consensus is clinically more useful than the conventional Gleason score (CGS), we compared the CGS and ISUP GS (IGS) of prostate needle biopsy (NB) and radical prostatectomy (RP) specimens, and evaluated the prognostic value of the ISUP GS. PATIENTS AND METHODS: Of 250 patients undergoing RP, 103 with clinical stage T1-2 N0M0 were enrolled. Pathological tumour grades of NB and RP specimens were classified according to CGS by experienced pathologists in the central pathology department of our hospital, and retrospectively according to IGS by one uropathologist at the central pathology department of another hospital. All patients had RP with no neoadjuvant or adjuvant therapy. We analysed associations of CGS and IGS with biochemical recurrence-free survival (BRFS) after RP. RESULTS: The concordance rates between NB and RP specimens by CGS and IGS were 64.1% and 69.9%. Under-grading and over-gradingrates by CGS and IGS were 28.2% and 7.8% for NB, and 27.2% and 2.9% for RP, respectively. There was a significant difference in the over-grading rate between CGS and IGS (P = 0.026). When CGS and IGS of NB and RP specimens were compared, the concordance rates were similar, at 67% and 69.9%. The IGS was higher, by 15.6% in NB and by 20.4% in RP specimens, than CGS. Patients were divided into three groups based on IGS of NB specimens (< or =6, 7 and > or =8). These groups differed significantly in BRFS after RP (P = 0.022); CGS showed no such association. CONCLUSIONS: The IGS of NB specimens were significantly associated with BRFS after RP. The ISUP system is thus clinically useful for determining the most appropriate treatments for patients with early-stage prostate cancer.
机译:目的:为了确定2005年国际泌尿外科病理学会(ISUP)格里森评分共识在临床上是否比常规格里森评分(CGS)更有用,我们比较了前列腺穿刺活检(NB)和根治性前列腺癌的CGS和ISUP GS(IGS)前列腺切除术(RP)标本,并评估ISUP GS的预后价值。患者与方法:在250例接受RP的患者中,纳入了103例临床分期为T1-2 N0M0的患者。 NB和RP标本的病理肿瘤分级由经验丰富的病理学家根据我院中央病理科的CGS分类,并由IUG回顾由另一家医院中央病理科的尿路病理学家进行分类。所有患者均接受RP,无新辅助治疗或辅助治疗。我们分析了CGS和IGS与RP后的生化无复发生存率(BRFS)的关联。结果:CGS和IGS在NB和RP样本之间的符合率分别为64.1%和69.9%。 NB的CGS和IGS的不及格分数和过高的分数分别为NB的28.2%和7.8%,RP的分别为27.2%和2.9%。 CGS和IGS之间的过度分级率存在显着差异(P = 0.026)。比较NB和RP标本的CGS和IGS时,一致率相似,分别为67%和69.9%。 IGS高于CGS,在NB中比在标本中高15.6%,在RP标本中比2GS高。根据NB标本的IGS将患者分为三组(<或= 6、7和>或= 8)。 RP后,这些组的BRFS差异显着(P = 0.022); CGS没有显示出这种关联。结论:RP后NB样本的IGS与BRFS显着相关。因此,ISUP系统在临床上可用于确定早期前列腺癌患者的最合适治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号