Double electrooxidative C-H functionalization of (het)arenes with thiocyanate and 4-nitropyrazolate ions

摘要

The double anodic C-H functionalization of N-methyl-1H-pyrrole and N,N-dimethylaniline using both thiocyanate and 4-nitro-1H-pyrazolate ions as nucleophiles has been accomplished for the first time. The mild reaction conditions and considerable pharmacological activity of the target products make such C-S and C-N coupling strategy to be highly attractive for further applications.