Synthesis and antiproliferative activity of new chlorin e(6) glycoconjugates

Kuzmina Natalia S.; Otvagin Vasilii F.; Krylova Lubov V.; Nyuchev Alexander V.; Romanenko Yuliya V.; Koifman Oscar I.; Balalaeva Irina V.; Fedorov Alexey Yu.

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Synthesis and antiproliferative activity of new chlorin e(6) glycoconjugates

机译：新型氯庚蛋白糖缀合物的合成与抗增殖活性

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摘要

New water soluble conjugates of chlorin e(6) derivative-zinc complex with beta-d-galactose or beta-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of similar to 50.

机译：用β-D-半乳糖或β-D-葡萄糖的新水溶性缀合物与β-D-半乳糖或β-D-葡萄糖合成为癌症光动力治疗的潜在剂。它们以低微摩尔浓度在具有IC50（暗）/ IC50（光）比例的低微摩尔浓度下表现出光诱导的细胞毒性与50相似。

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《Mendeleev Communications》 |2020年第2期|共3页
作者
Kuzmina Natalia S.; Otvagin Vasilii F.; Krylova Lubov V.; Nyuchev Alexander V.; Romanenko Yuliya V.; Koifman Oscar I.; Balalaeva Irina V.; Fedorov Alexey Yu.;
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作者单位

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

Ivanovo State Univ Chem &

Technol Res Inst Macroheterocycles Ivanovo 153000 Russia;

Ivanovo State Univ Chem &

Technol Res Inst Macroheterocycles Ivanovo 153000 Russia;

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

NI Lobachevsky State Univ Nizhny Novgorod Nizhnii Novgorod Russia;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
chlorin e(6); glycoconjugate; water soluble; A431 cells; photodynamic therapy;

机译：氯e（6）;糖缀合物;水溶性;A431细胞;光动力疗法;

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专利

1. Synthesis and antiproliferative activity of new chlorin e(6) glycoconjugates [J] . Kuzmina Natalia S., Otvagin Vasilii F., Krylova Lubov V., Mendeleev Communications . 2020,第2期

机译：新型氯庚蛋白糖缀合物的合成与抗增殖活性
2. Synergistic antiproliferative effect of chemo-phototherapy: Synthesis and photodynamic activity evaluation of novel Chlorin e6-artesunate conjugates as antiproliferative agents [J] . Xiuhan Guo, Liu Wang, Shisheng Wang, Bioorganic and Medicinal Chemistry Letters . 2017,第19期

机译：化学光疗协同抗增殖效应：新型氯化叶片E6-艺术缀合物的合成与光动力活动评价作为抗增殖剂
3. Synthesis and antiproliferative activity of a natural like glycoconjugate polycyclic compound [J] . Maggio Benedetta, Raimondi Maria Valeria, Raffa Demetrio, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2016,第Null期

机译：天然类糖缀合物多环化合物的合成及其抗增殖活性
4. ECO-FRIENDLY SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF CARBOHYDRATE-DERIVED HETEROCYCLES [C] . Veronica Luque-Aqudo, M Victoria Gil-Alvarez International Carbohydrate Symposium . 2018

机译：碳水化合物衍生杂环的环保合成与抗增殖活性
5. Part I. Synthesis of novel antimalarial, antiproliferative and anticancer artemisinin-based triozane dimers. Part II. Silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones: Total synthesis of Phoracatholide I and Cephalosporolide D. [D] . Borstnik, Kristina. 2006

机译：第一部分：基于青蒿素的新型抗疟疾，抗增殖和抗癌三唑烷二聚体的合成。第二部分硅介导的n尺寸的共轭环烯酮的环扩环成均烯丙基n + 3内酯：邻苯三甲酚I和头孢甲酚D的全合成。
6. Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin) [O] . Mamoru Tanaka, Hiromi Kataoka, Shigenobu Yano, 2016

机译：糖缀合二氢卟酚（G-chlorin）的新光动力疗法（PDT）导致免疫原性细胞死亡
7. Synthesis and antiproliferative activity of a natural like glycoconjugate polycyclic compound [O] . Maggio B., Raimondi M., Raffa D., 2016

机译：天然的类似糖缀合物的多环化合物的合成及其抗增殖活性

Synthesis and antiproliferative activity of new chlorin e(6) glycoconjugates

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