Antifatigue effects of troxerutin on exercise endurance capacity, oxidative stress and matrix metalloproteinase‐9 levels in trained male rats

摘要

Abstract The aim of this study was to investigate effects of troxerutin ( TRX ) on endurance capacity, oxidative stress and matrix metalloproteinase‐9 ( MMP ‐9) levels in trained male rats. Forty male Wistar rats were divided into five groups. The control (Vehicle) and exercise training (5?days/week) with vehicle treatment (Exercise), exercise training with TRX treatment at 75 (Ex‐ TRX 75), 150 (Ex‐ TRX 150), and 300?mg/kg (Ex‐ TRX 300). The treated groups received TRX by gavage every day while the other groups received water for 30?days. On the 30th day, rats were sacrificed immediately after exhaustive swimming test, and some biochemical parameters were measured. Exhaustion swimming time in the Ex‐ TRX 75, Ex‐ TRX 150 and Ex‐ TRX 300 groups significantly increased 1.2‐, 1.93‐ and 2.1‐fold compared to the vehicle group, respectively. TRX significantly increased glucose level ( P? ? 0.05) and reduced creatine kinase activity ( P? ?0.001) compared to the vehicle and exercise groups. TRX 300 significantly reduced alkaline phosphatase and lactate dehydrogenase activities ( P? ?0.05) and blood urea nitrogen ( P? ?0.05) and MMP ‐9 levels ( P? ?0.05) compared to the vehicle and exercise groups. Additionally, TRX 300 and TRX 150 significantly increased superoxide dismutase activity compared to the vehicle group ( P? ?0.05). Our results provide experimental evidence in supporting clinical use of TRX as an effective agent against fatigue.