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Decellularized Periosteum‐Covered Chitosan Globule Composite for Bone Regeneration in Rabbit Femur Condyle Bone Defects

机译：用于兔股骨髁骨缺陷的骨再生脱细胞化骨膜覆盖的壳聚糖球形复合材料

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Abstract >Critical‐sized bone defects are incapable of self‐healing and are commonly seen in clinical practice. The authors explore a new treatment for this, decellularized periosteum is applied to chitosan globules (chitosan‐DP globules) as a hybrid material. The efficacy of chitosan‐DP globules on rabbit femoral condyle bone defects is assessed with biocompatibility, biomechanics, and osteogenic efficiency measurements, and compared with the results of chitosan globules and empty control. No difference in cytotoxicity is observed among chitosan‐DP globules, chitosan globules, and the empty control. Chitosan‐DP globules possesse a better surface for cell adhesion than did chitosan globules. Chitosan‐DP globules demonstrate superior efficiency for osteogenesis in the defect area compared to chitosan globules as per microcomputed tomography examination and push‐out testing, with relatively minor histological differences. Both chitosan globule groups show more satisfactory results than those for the empty control. The results implicate chitosan‐DP globules as a promising solution for bone defects. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>摘要</ title> >临界骨缺陷无法自我修复，并且在临床实践中常见。作者探讨了这种新的处理，将脱细胞骨膜膜作为杂化材料应用于壳聚糖球（壳聚糖-DP小球）。用生物相容性，生物力学和成骨效率测量评估壳聚糖-DP小球对兔股髁髁骨缺陷的疗效，并与壳聚糖小球和空对照的结果进行了比较。在壳聚糖-DP小球，壳聚糖小球和空对照中，观察到细胞毒性没有差异。壳聚糖-DP小球体具有比壳聚糖球的细胞粘附更好的表面。壳聚糖-DP球苗表现出与壳聚糖球的缺陷面积中骨质发生的卓越效率，与壳聚糖球体相比，具有相对较小的组织学差异。壳聚糖球粒均显示出比空控制的结果更令人满意。结果将壳聚糖-DP小球牵引为骨缺损的有希望的解决方案。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-24307/'>《Macromolecular bioscience》</a> <b style="margin: 0 2px;">|</b><span>2018年第9期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Yiheng&option=202" target="_blank" rel="nofollow">Ye Yiheng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pang Yichuan&option=202" target="_blank" rel="nofollow">Pang Yichuan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Zeng&option=202" target="_blank" rel="nofollow">Zhang Zeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wu Congcong&option=202" target="_blank" rel="nofollow">Wu Congcong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Jianfeng&option=202" target="_blank" rel="nofollow">Jin Jianfeng;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Su Mingzhen&option=202" target="_blank" rel="nofollow">Su Mingzhen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pan Junle&option=202" target="_blank" rel="nofollow">Pan Junle;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yangbo&option=202" target="_blank" rel="nofollow">Liu Yangbo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Lei&option=202" target="_blank" rel="nofollow">Chen Lei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Keke&option=202" target="_blank" rel="nofollow">Jin Keke;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of OrthopedicsThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000 China;</p> <p>Department of Oral and Maxillofacial SurgeryShanghai Jiao Tong University School of MedicineShanghai 200000 China;</p> <p>First Academy of Clinical MedicineWenzhou Medical UniversityWenzhou 325000 China;</p> <p>First Academy of Clinical MedicineWenzhou Medical UniversityWenzhou 325000 China;</p> <p>First Academy of Clinical MedicineWenzhou Medical UniversityWenzhou 325000 China;</p> <p>First Academy of Clinical MedicineWenzhou Medical UniversityWenzhou 325000 China;</p> <p>First Academy of Clinical MedicineWenzhou Medical UniversityWenzhou 325000 China;</p> <p>Department of OrthopedicsThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000 China;</p> <p>Department of OrthopedicsThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000 China;</p> <p>Department of PathophysiologyWenzhou Medical UniversityWenzhou 325000 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bone defect&option=203" rel="nofollow">bone defect;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=chitosan&option=203" rel="nofollow">chitosan;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=composite biomaterials&option=203" rel="nofollow">composite biomaterials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=decellularized periosteum&option=203" rel="nofollow">decellularized periosteum;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=regenerative medicine&option=203" rel="nofollow">regenerative medicine;</a> </p> <div class="translation"> 机译：骨缺损;壳聚糖;复合生物材料;脱细胞骨膜;再生医学; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023543094.html">Decellularized Periosteum‐Covered Chitosan Globule Composite for Bone Regeneration in Rabbit Femur Condyle Bone Defects</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Yiheng&option=202" 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tuijian_authcolor">,刘海峰</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2007</span><span>,第048期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-tissue-engineering-research_thesis/0201252242130.html">生物衍生骨体外复合构建组织工程化骨修复兔桡骨-骨膜缺损:血管化进程及其生物力学性能</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马雪峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马雪峰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱肖奇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱肖奇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贺用礼&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贺用礼</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2010</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-tissue-engineering-research_thesis/0201252323200.html">生物衍生骨复合成骨诱导骨髓间充质干细胞构建组织工程化骨修复兔桡骨-骨膜缺损的血管化进程</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱肖奇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱肖奇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马雪峰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,马雪峰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=贺用礼&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,贺用礼</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2008</span><span>,第027期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-tissue-engineering-research_thesis/0201252598343.html">游离骨膜骨髓磷酸钙复合移植应用于膜引导性骨再生的实验研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邹国耀&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邹国耀</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李振荣&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李振荣</a> <span> <a href="/journal-cn-15352/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国组织工程研究 </a> </span> <span> . 2004</span><span>,第026期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-17843_thesis/020221915552.html">rhBMP-2/异体骨复合骨用于兔腰椎融合的实验研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/conference-cn-17843/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第二届全国骨关节结核病专题研讨会 </a> <span> <span> . 2008</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312270666.html">矿化小肠粘膜下层脱细胞基质/煅烧骨多孔复合材料诱导骨再生实验研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙亭方&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 孙亭方</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204907329.html">一种由羊骨膜脱细胞基质制备的口腔引导骨再生膜及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN110384826B </span> <span> . 2022.02.15</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101141865.html">一种由羊骨膜脱细胞基质制备的口腔引导骨再生膜及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN110384826A </span> <span> . 2019-10-29</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130501073740.html">METHOD FOR MODELING A BONE TISSUE DEFECT FOR STUDYING OSSEOINTEGRATION OF OSTEOPLASTIC MATERIAL AND REGENERATION OF CANCELLOUS BONE TISSUE IN AN EXPERIMENT ON RABBITS</a> <b>[P]</b> . <span> 外国专利：  RU2758556C1 </span> <span> . 2021-10-29</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于研究骨组织缺陷的方法，用于研究骨质塑料材料骨整合和松质骨组织再生在兔子的实验中 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130434117835.html">Device for accommodation of fracture of femur, tibia or humerus, has nail insertable in medullary space of bones, and rigid shaft of nail extends into condyle massive of bone where section of changing form is arranged at distal end of shaft</a> <b>[P]</b> . <span> 外国专利：  DE102006005370A1 </span> <span> . 2007-08-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于容纳股骨，胫骨或肱骨骨折的装置，其钉子可插入骨的髓腔中，并且钉子的刚性轴伸入骨的massive突中，其中变型部分设置在轴的远端 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130422412339.html">THE PRESENT INVENTION RELATES TO A BONE SUBSTITUTE COMPRISING A CORE BASED ON HYDROXYAPATITE (HA), OBTAINED FROM AT LEAST ONE POROUS WOOD, OR BASED ON COLLAGEN FIBRES AND HYDROXYAPATITE, AND A SHELL, BASED ON HYDROXYAPATITE (HA) OR SILICON CARBIDE (SIC), OBTAINED FROM AT LEAST ONE WOOD HAVING A LOWER POROSITY THAN THE AT LEAST ONE WOOD OF THE CORE. THE POROUS WOOD HAS A TOTAL POROSITY OF BETWEEN 60 AND 95, PREFERABLY BETWEEN 65 AND 85, AND IT IS SELECTED FROM AMONGST THE CHOICES OF RATTAN, PINE, ABACHI AND BALSA WOOD. THE WOOD OF THE SHELL HAS A POROSITY OF BETWEEN 20 AND 60, PREFERABLY BETWEEN 30 AND 50. THE BONE SUBSTITUTE IS UTILIZED FOR THE SUBSTITUTION AND REGENERATION OF BONE, PREFERABLY FOR BONES SUBJECTED TO MECHANICAL LOADS, SUCH AS LONG BONES OF THE LEG AND ARM, PREFERABLY THE TIBIA, METATARSUS, FEMUR, HUMERUS OR RADIUS.</a> <b>[P]</b> . <span> 外国专利：  WO2012063201A1 </span> <span> . 2012-05-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：本发明涉及包含基于羟基磷灰石（HA）的核心的骨替代物，所述核心取自至少一种多孔木材，或者基于胶原纤维和羟基磷灰石，以及基于羟基磷灰石（HA）的壳，是从至少一木材获得的，其孔隙率比核心的至少一木材低。多孔木材的总孔隙率在60％和95％之间，最好在65％和85％之间，并且可以从藤，松木，ABACHI和BALSA木材中选择。外壳的木材的孔隙率在20％和60％之间，最好在30％和50％之间。骨骼替代物可用于骨骼的替代和再生，尤其适用于承受机械载荷的骨骼，例如腿和手臂的长骨，通常是胫骨，变角肌，股骨，肱骨或RADIUS。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div 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