Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase

摘要

Aim: There is little information available on the monoamine oxidase isoform selectivity of N-alkyl harmine analogs, which exhibit a myriad of activities including MAO-A, DYRK1A and cytotoxicity to several select cancer cell lines. Results: Compounds 3e and 4c exhibited an IC50 of 0.83 +/- 0.03 and 0.43 +/- 0.002M against MAO-A and an IC50 of 0.26 +/- 0.04 and 0.36 +/- 0.001M against MAO-B, respectively. Molecular docking studies revealed - interactions between the synthesized molecules and aromatic amino acid residues. Conclusion & future perspective: The current study delineates the structural requirements for MAO-A selectivity and such information may be helpful in designing selective analogs for kinase, DYRK1A and harmine-based cytotoxics without apparent MAO enzyme inhibition.