Fluorescently Labeled Protein-Polymer Bioconjugates Using Protein-Derived Macroinitiators from Living Radical Polymerization

摘要

Bovine Serum Albumin (BSA) and lysozyme have been chemically transformed into macroinitiators for the synthesis of fluorescent bioconjugates by living radical polymerization. A new fluorescent monomer based on rhodamine B has been synthesized and incorporated into the polymer backbone of the bioconjugate by copolymerization. This provides a new strategy for the synthesis of fluorescent bioconjugates with improved traceability in biological environments, during biomedical assays.