Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and Transforming Growth Factor-beta 1 Expression in Diabetic Foot Wounds

摘要

Background: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can putatively facilitate wound healing, but the underlying mechanisms remain unclear. Cellular fibronectin (cFN) and transforming growth factor-beta 1 (TGF-beta 1) play an important role in wound healing. This prospective randomized controlled trial evaluated the effects of NPWT on the production of cFN and the expression of TGF-beta 1 in diabetic foot wounds of patients.