To highlight recent advances in stem cell-based regenerative rehabilitation for promoting tissue repair. Recently, regenerative medicine including stem cell therapeutics and tissue engineering has offered new approaches for the development of complex biological therapies. But, the biophysical and biochemical factors that determine their success needs to be better understood. The compatibility of the host and the donor factors still pose a challenge for the regenerative medicine. The inclusion of the mechanotransductive principles for regenerating and repairing damaged cells offers opportunities for advancement in regenerative medicine. Also, the combination of regenerative medicine with the rehabilitative principles has the potential to create new approaches for the treatment of tissue injury or tissue disease, paving the path to a new branch known as regenerative rehabilitation. This study focuses on the synergy between rehabilitation strategies and regenerative response. The stem cell therapies have yielded success with long-term efficacy. The recovery after transplantation is mostly due to paracrine effects of the transplanted cells.
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