Determination of fumonisin B-1 levels in body fluids and hair from piglets fed fumonisin B-1-contaminated diets

摘要

The levels of fumonisin B-1 (FBI) residues in plasma, urine, feces and hair from 24 piglets fed FB1-contaminated diets containing 3.1, 6.1 or 9.0 mu g FB1.g(-1) for 28 days were determined using liquid chromatography coupled to mass spectrometry (LC-MS/MS). The levels of FB1 in plasma, urine, feces and pooled hair (n = 3) samples varied from 0.15 to 1.08 mu g.L-1, 16.09-75.01 mu g.L-1, 1.87-13.89 mu g.g(-1) and 2.08-8.09 ng.g(-1), respectively. Significant correlations (r = 0.808-0.885; P 14 days). The possibility to evaluate hair as a biomarker of fumonisin exposure was established, although further studies are needed to provide physiologically based toxicokinetics of residual FB1 in the pig hair. (C) 2017 Elsevier Ltd. All rights reserved.