Two novel terpenoids from the cultured ce:italic>Perovskia atriplicifolia/ce:italic>

摘要

Two new terpenoids, named biperovskatone B (1) and 1α- hydroxyl demethylsalvicanol quinine (2), were isolated from the culturedPerovskia atriplicifolia. Their structures were elucidated by comprehensive analyses of the MS, IR, 1D and 2D NMR spectra. Compound1was a novel diterpenoid dimer, containing two different rearranged 9(10?→?20)-abeoabietane type diterpenoid fragments. Compound2was a new icetexane diterpenoid with characteristicortho-quinone carbonyl groups. Both compounds were assayed for their anti-HBV activity in vitro. Results suggested compounds1and2showed noticeable anti- anti-HBV activity, inhibiting the replication of HBV DNA with IC50values of 10.78 and 8.61?μM, respectively.