Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey.

摘要

OBJECTIVE: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in Sao Paulo, Brazil. DESIGN: Population-based questionnaire study. SETTING: Interviews, sleep recording, and blood sample were conducted in a sleep institute. PATIENT(S): The total study participants included 467 men. INTERVENTION(S): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping. MAIN OUTCOME MEASURE(S): The effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample. RESULT(S): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED (odds ratio = 0.80; 95% confidence interval = 0.40-1.62). CONCLUSION(S): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. The results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect.