Current Gene Therapy Strategy for Renal Cell Carcinoma

摘要

Renal cell carcinoma (RCC) is the third most common urologic neoplasm and its age-adjusted incidence has been increasing annually. Despite advances in cancer research and current therapy strategies, the effective treatment of advanced RCC remains elusive. Over the past two decades, clinical and genetic studies have shown that kidney cancer is not a single disease entity, rather a spectrum of different forms. This understanding has translated into therapies targeted against specific genetic targets. In this review, we highlight the scientific principles, current applications, and future direction of renal cell cancer gene therapy.