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首页> 外文期刊>Advances in Food Sciences >HEPATOPROTECTIVE ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACT OF LEPIDIUM SATIVUM L. SEEDS AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
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HEPATOPROTECTIVE ACTIVITY OF AQUEOUS AND ALCOHOLIC EXTRACT OF LEPIDIUM SATIVUM L. SEEDS AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

机译:水和乙醇提取物对四氯化碳诱导的大鼠肝毒性的抑制作用

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摘要

Protective actions of Lepidium sativum L. aqueous and alcoholic extracts were evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (CCL). Male albino rats were divided into 10 groups. Group Gl was normal control group; groupsG2-G10 received CCL (paraffin oil, 25 ul/kg b.w.). After inducing hepatic damage, group G2 served as control for CCL; groups G3-G5 received different doses of Lepidium sativum ethanol extract (200, 400 and 800 mg/kg), groups G6-G8 received different doses of Lepidium sativum aqueous extract (50, 100 and 150 mg/kg), respectively, for 60 days. The activities of extracts were also comparable to that of two standard drugs Ursoplus 5.6 mg/kg and Hepa-Merz 71.4 mg/kg (G9) and Legalon 6 mg/kg (G10), known ashepatoprotec-tive. Alteration in the levels of biochemical markers of hepatic damage were tested in all groups. Sections of livers were observed under the microscope for the histopathologi-cal changes. Levels of marker enzymes, such as ALT, AST, ALP, total bilirubin, and direct bilirubin, were increased significantly (p<0.05) in CCL treated rats (group 2). In groups 3-10, decreased activities of these enzymes were observed. In addition, treatment of CCL (positive control) resulted in markedly decreasedlevels of superoxide dismutase and catalase enzymes in rats. Treatment of the rats with Lepidium sativum L. aqueous and alcoholic extracts with CCL, administration caused a significant reduction in the values of hydrogen peroxide, y-glutamyl transferase,MDA, total cholesterol and LDL (P<0.05), almost comparable to the standard drugs. The extract also similarly caused a significant (p<0.05) increase in HDL values compared with CCL-treated group, and liver weight with respect to CCLt-toxic rats. Histopathological profiles showed that out of all the extracts, ethanol and aqueous extracts had significant protective effect against CCLt-induced liver injury which is comparable with the standard drug. Thus, the results suggest that Lepidium sativum aqueous and alcoholic extracts acts as a potent hepatoprotective agent against CCLt-induced hepatotoxicity in rats.
机译:在由四氯化碳(CCL)诱导的肝毒性动物模型中评估了番茄鳞茎水提物和酒精提取物的保护作用。将雄性白化病大鼠分为10组。 G1组为正常对照组。 G2-G10组接受CCL(石蜡油,25 ul / kg体重)。诱导肝损伤后,G2组作为CCL的对照组。 G3-G5组分别接受60毫克/千克,200毫克/千克和800毫克/千克的不同剂量的淫羊ethanol乙醇提取物,G60-G8组分别接受60毫克/千克,50毫克/千克和150毫克/千克的不同剂量的迷迭香水提取物。天。提取物的活性也可与两种已知的烟粉防护药物Ursoplus 5.6 mg / kg和Hepa-Merz 71.4 mg / kg(G9)和Legalon 6 mg / kg(G10)媲美。在所有组中测试肝损伤的生化标志物水平的变化。在显微镜下观察肝脏切片的组织病理学变化。在CCL治疗的大鼠(第2组)中,诸如ALT,AST,ALP,总胆红素和直接胆红素等标记酶的水平显着增加(p <0.05)。在3-10组中,观察到这些酶的活性降低。此外,CCL(阳性对照)的治疗导致大鼠超氧化物歧化酶和过氧化氢酶的水平明显降低。用覆铜板处理鼠尾草水和酒精提取物对大鼠的治疗导致过氧化氢,γ-谷氨酰转移酶,MDA,总胆固醇和LDL值显着降低(P <0.05),几乎与标准相当毒品。与CCL处理组相比,提取物还同样导致HDL值显着(p <0.05)升高,并且相对于CCLt毒性大鼠,肝脏重量增加。组织病理学特征表明,在所有提取物中,乙醇和水提取物对CCLt诱导的肝损伤具有明显的保护作用,与标准药物相当。因此,该结果表明,番茄小叶菊水和酒精提取物可作为有效的肝保护剂,抵抗CCLt诱导的大鼠肝毒性。

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