Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

Moller Pal; Seppala Toni T.; Bernstein Inge; Holinski-Feder Elke; Sala Paulo; Evans D. Gareth; Lindblom Annika; Macrae Finlay; Blanco Ignacio; Sijmons Rolf H.; Jeffries Jacqueline; Vasen Hans F. A.; Burn John; Nakken Sigve; Hovig Eivind; Rodland Einar Andreas; Tharmaratnam Kukatharmini; Cappel Wouter H. de Vos Tot Nederveen; Hill James; Wijnen Juul T.; Jenkins Mark A.; Green Kate; Lalloo Fiona; Sunde Lone; Mints Miriam; Bertario Lucio; Pineda Marta; Navarro Matilde; Morak Monika; Renkonen-Sinisalo Laura; Valentin Mev Dominguez; Frayling Ian M.; Plazzer John-Paul; Pylvanainen Kirsi; Genuardi Maurizio; Mecklin Jukka-Pekka; Moeslein Gabriela; Sampson Julian R.; Capella Gabriel

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Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

机译：基因和性别的癌症风险和生存在Path_MMR载体中，最高可达75岁：预期林奇综合征数据库的报告

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Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists with respect to cancer risk and survival.

机译：背景技术大多数患有PATH_MMR基因变体的患者（LYNCH综合征（LS））现在存活他们的第一个和后续癌症，导致患有有限信息的LS越来越多的患者，这些患者存在于癌症风险和生存率有限。

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来源
《Gut: Journal of the British Society of Gastroenterology》 |2018年第7期|共11页
作者
Moller Pal; Seppala Toni T.; Bernstein Inge; Holinski-Feder Elke; Sala Paulo; Evans D. Gareth; Lindblom Annika; Macrae Finlay; Blanco Ignacio; Sijmons Rolf H.; Jeffries Jacqueline; Vasen Hans F. A.; Burn John; Nakken Sigve; Hovig Eivind; Rodland Einar Andreas; Tharmaratnam Kukatharmini; Cappel Wouter H. de Vos Tot Nederveen; Hill James; Wijnen Juul T.; Jenkins Mark A.; Green Kate; Lalloo Fiona; Sunde Lone; Mints Miriam; Bertario Lucio; Pineda Marta; Navarro Matilde; Morak Monika; Renkonen-Sinisalo Laura; Valentin Mev Dominguez; Frayling Ian M.; Plazzer John-Paul; Pylvanainen Kirsi; Genuardi Maurizio; Mecklin Jukka-Pekka; Moeslein Gabriela; Sampson Julian R.; Capella Gabriel;
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作者单位

Oslo Univ Hosp Norwegian Radium Hosp Dept Med Genet Oslo Norway;

Univ Helsinki Helsinki Univ Cent Hosp Dept Gastrointestinal Surg Helsinki Finland;

Copenhagen Univ Hosp Clin Res Ctr Danish Hereditary Nonpolyposis Colorectal Canc Re Hvidovre;

Klinikum Univ Munchen Med Klin &

Poliklin 4 Campus Innenstadt Ziemssenstr Germany;

IRCCS Ist Nazl Tumori Milan Unit Hereditary Digest Tract Tumors Milan Italy;

Cent Manchester Univ Hosp NHS Fdn Trust Manchester Ctr Genom Med London England;

Karolinska Inst Dept Mol Med &

Surg Stockholm Sweden;

Royal Melbourne Hosp Colorectal Med &

Genet Melborne Australia;

IDIBELL Inst Catala Oncol Hereditary Canc Program Barcelona Spain;

Univ Groningen Univ Med Ctr Groningen Dept Genet Groningen Netherlands;

Cardiff Univ Sch Med Inst Med Genet Div Canc &

Genet Hth Pk Cardiff S Glam Wales;

Leiden Univ Med Ctr Dept Gastroenterol &

Hepatol Leiden Netherlands;

Newcastle Univ Inst Genet Med Newcastle Upon Tyne Tyne &

Wear England;

Oslo Univ Hosp Norwegian Radium Hosp Inst Canc Res Dept Tumor Biol Oslo Norway;

Oslo Univ Hosp Norwegian Radium Hosp Inst Canc Res Dept Tumor Biol Oslo Norway;

Oslo Univ Hosp Norwegian Radium Hosp Inst Canc Res Dept Tumor Biol Oslo Norway;

Univ Lancaster Dept Math &

Stat Lancaster England;

Isala Clin Dept Gastroenterol &

Hepatol Zwolle Netherlands;

Cent Manchester Univ Hosp NHS Fdn Trust Dept Surg London England;

Univ Med Ctr Dept Clin Genet Leiden Netherlands;

Univ Melbourne Melbourne Sch Populat &

Global Hlth Ctr Epidemiol &

Biostat Parkville Vic;

Cent Manchester Univ Hosp NHS Fdn Trust Manchester Ctr Genom Med London England;

Cent Manchester Univ Hosp NHS Fdn Trust Manchester Ctr Genom Med London England;

Aalborg Univ Hosp Dept Surg Gastroenterol Aalborg Denmark;

Karolinska Inst Karolinska Univ Hosp Div Obstet &

Gyneacol Dept Womens &

Childrens Hlth;

IRCCS Ist Nazl Tumori Milan Unit Hereditary Digest Tract Tumors Milan Italy;

IDIBELL Inst Catala Oncol Hereditary Canc Program Barcelona Spain;

IDIBELL Inst Catala Oncol Hereditary Canc Program Barcelona Spain;

Klinikum Univ Munchen Med Klin &

Poliklin 4 Campus Innenstadt Ziemssenstr Germany;

Univ Helsinki Helsinki Univ Cent Hosp Dept Gastrointestinal Surg Helsinki Finland;

Oslo Univ Hosp Norwegian Radium Hosp Dept Med Genet Oslo Norway;

Royal Melbourne Hosp Colorectal Med &

Genet Melborne Australia;

Cent Finland Hlth Care Dist Dept Educ &

Sci Yvaskyla Finland;

Univ Cattolica Sacro Cuore A Gemelli Fac Med Inst Genom Med Rome Italy;

Univ Eastern Finland Kuopio Finland;

Cardiff Univ Sch Med Inst Med Genet Div Canc &

Genet Hth Pk Cardiff S Glam Wales;

IDIBELL Inst Catala Oncol Hereditary Canc Program Barcelona Spain;

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正文语种 eng
中图分类消化系及腹部疾病;
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专利

1. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database [J] . Moller Pal, Seppala Toni T., Bernstein Inge, Gut: Journal of the British Society of Gastroenterology . 2018,第7期

机译：基因和性别的癌症风险和生存在Path_MMR载体中，最高可达75岁：预期林奇综合征数据库的报告
2. Response to Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [J] . Genetics in medicine . 2020,第4期

机译：响应响应Dominguez-Valentin M等人。 2019年：癌症风险由基因，年龄和性别在6350年的致病失配修复变体：从前瞻性林奇综合征数据库的调查结果
3. Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [J] . Genetics in medicine . 2020,第4期

机译：对Dominguez-Valentin M等人的回应。 2019年：癌症风险由基因，年龄和性别在6350年的致病失配修复变体：从前瞻性林奇综合征数据库的调查结果
4. Diabetes Risk Obese Among Indonesian Adults with Metabolic Syndrome by 6-Years Prospective Cohort Study [C] . Ekowati Rahajeng, Eva Sulistiowati, Nunik Kusumawardhani International Symposium on Health Research;National Congress of The Indonesian Public Health Association . 2020

机译：糖尿病在印度尼西亚成年人中患有代谢综合征的糖尿病风险肥胖，6年前瞻性队列研究
5. Modifier genes and susceptibility to colorectal cancer in individuals with Lynch syndrome [D] . Pande, Mala 2007

机译：Lynch综合征患者的修饰基因和对结直肠癌的易感性
6. Original article: Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database [O] . Pål Møller, Toni T Seppälä, Inge Bernstein, -1

机译：原始文章：高达75岁的按基因和性别分类的path_MMR携带者中path_MMR携带者的癌症风险和生存率：前瞻性林奇综合症数据库的报告
7. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age; a report from the Prospective Lynch Syndrome Database [O] . Moller, Pal, Seppälä, Toni, Bernstein, Inge, 2017

机译：path_mmR携带者的癌症风险和存活率基因和性别高达75岁;前瞻性Lynch综合症数据库的报告

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

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