Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study

Hart M. Ragan; Biesecker Barbara B.; Blout Carrie L.; Christensen Kurt D.; Amendola Laura M.; Bergstrom Katie L.; Biswas Sawona; Bowling Kevin M.; Brothers Kyle B.; Conlin Laura K.; Cooper Greg M.; Dulik Matthew C.; East Kelly M.; Everett Jessica N.; Finnila Candice R.; Ghazani Arezou A.; Gilmore Marian J.; Goddard Katrina A. B.; Jarvik Gail P.; Johnston Jennifer J.; Kauffman Tia L.; Kelley Whitley V.; Krier Joel B.; Lewis Katie L.; McGuire Amy L.; McMullen Carmit; Ou Jeffrey; Plon Sharon E.; Rehm Heidi L.; Richards C. Sue; Romasko Edward J.; Sagardia Ane Miren; Spinner Nancy B.; Thompson Michelle L.; Turbitt Erin; Vassy Jason L.; Wilfond Benjamin S.; Veenstra David L.; Berg Jonathan S.; Green Robert C.; Biesecker Leslie G.; Hindorff Lucia A.

首页> 外文期刊>Genetics in medicine >Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study

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Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study

机译：来自临床基因组测序的二次结果：普遍存在，患者观点，家族历史评估和多重研究的医疗费用

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摘要

Purpose: Clinical sequencing emerging in health care may result in secondary findings (SFs).

机译：目的：在医疗保健中出现的临床测序可能导致次要发现（SFS）。

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来源
《Genetics in medicine》 |2019年第5期|共11页
作者
Hart M. Ragan; Biesecker Barbara B.; Blout Carrie L.; Christensen Kurt D.; Amendola Laura M.; Bergstrom Katie L.; Biswas Sawona; Bowling Kevin M.; Brothers Kyle B.; Conlin Laura K.; Cooper Greg M.; Dulik Matthew C.; East Kelly M.; Everett Jessica N.; Finnila Candice R.; Ghazani Arezou A.; Gilmore Marian J.; Goddard Katrina A. B.; Jarvik Gail P.; Johnston Jennifer J.; Kauffman Tia L.; Kelley Whitley V.; Krier Joel B.; Lewis Katie L.; McGuire Amy L.; McMullen Carmit; Ou Jeffrey; Plon Sharon E.; Rehm Heidi L.; Richards C. Sue; Romasko Edward J.; Sagardia Ane Miren; Spinner Nancy B.; Thompson Michelle L.; Turbitt Erin; Vassy Jason L.; Wilfond Benjamin S.; Veenstra David L.; Berg Jonathan S.; Green Robert C.; Biesecker Leslie G.; Hindorff Lucia A.;
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作者单位

Univ Washington Dept Med Med Genet Seattle WA 98195 USA;

NHGRI Social &

Behav Res Branch NIH Bethesda MD 20892 USA;

Brigham &

Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA;

Brigham &

Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA;

Univ Washington Dept Med Med Genet Seattle WA 98195 USA;

Baylor Coll Med Dept Pediat Oncol Sect Houston TX 77030 USA;

Childrens Hosp Philadelphia Dept Pediat Div Human Genet Philadelphia PA 19104 USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Univ Louisville Dept Pediat Louisville KY 40292 USA;

Childrens Hosp Dept Pathol &

Lab Med Div Genom Diagnost Philadelphia PA 19104 USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Childrens Hosp Dept Pathol &

Lab Med Div Genom Diagnost Philadelphia PA 19104 USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Univ Michigan Dept Internal Med Ann Arbor MI 48109 USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Kaiser Permanente Northwest Dept Med Genet Portland OR USA;

Kaiser Permanente Northwest Ctr Hlth Res Portland OR USA;

Univ Washington Dept Med Med Genet Seattle WA 98195 USA;

NHGRI Med Genom &

Metab Genet Branch NIH Bethesda MD 20892 USA;

Kaiser Permanente Northwest Ctr Hlth Res Portland OR USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

Brigham &

Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA;

NHGRI Med Genom &

Metab Genet Branch NIH Bethesda MD 20892 USA;

Baylor Coll Med Ctr Med Eth &

Hlth Policy Houston TX 77030 USA;

Kaiser Permanente Northwest Ctr Hlth Res Portland OR USA;

Univ Washington Clin Sequencing Exploratory Res Coordinating Ctr Seattle WA 98195 USA;

Baylor Coll Med Dept Pediat Oncol Sect Houston TX 77030 USA;

Harvard Med Sch Boston MA 02115 USA;

Oregon Hlth &

Sci Univ Knight Diagnost Labs Portland OR USA;

Childrens Hosp Dept Pathol &

Lab Med Div Genom Diagnost Philadelphia PA 19104 USA;

NHGRI Social &

Behav Res Branch NIH Bethesda MD 20892 USA;

Childrens Hosp Dept Pathol &

Lab Med Div Genom Diagnost Philadelphia PA 19104 USA;

HudsonAlpha Inst Biotechnol Huntsville AL USA;

NHGRI Social &

Behav Res Branch NIH Bethesda MD 20892 USA;

Brigham &

Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA;

Univ Washington Dept Pediat Seattle WA 98195 USA;

Univ Washington Clin Sequencing Exploratory Res Coordinating Ctr Seattle WA 98195 USA;

Univ N Carolina Dept Genet Chapel Hill NC 27515 USA;

Brigham &

Womens Hosp Dept Med Div Genet 75 Francis St Boston MA 02115 USA;

NHGRI Med Genom &

Metab Genet Branch NIH Bethesda MD 20892 USA;

NHGRI Div Genom Med NIH Bethesda MD 20892 USA;

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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
genomic sequencing; secondary findings; health-care resource utilization;

机译：基因组测序;二次结果;卫生保健资源利用;

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专利

1. Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study (vol 21, pg 1100, 2019) [J] . Hart M. Ragan, Biesecker Barbara B., Blout Carrie L., Genetics in medicine . 2019,第5期

机译：临床基因组测序中的二次结果：普遍存在，患病率，患者观点，家族历史评估和来自多站立研究的医疗费用（Vol 21，PG 1100,2019）
2. Effectiveness of the Genomics ADvISER decision aid for the selection of secondary findings from genomic sequencing: a randomized clinical trial [J] . Genetics in medicine . 2020,第4期

机译：基因组学顾问决策援助从基因组测序选择中学结果的有效性：随机临床试验
3. "Not pathogenic until proven otherwise": perspectives of UK clinical genomics professionals toward secondary findings in context of a Genomic Medicine Multidisciplinary Team and the 100,000 Genomes Project [J] . Ormondroyd Elizabeth, Mackley Michael P., Blair Edward, Genetics in medicine . 2018,第3期

机译：“不致病，否则”：英国临床基因组学专业人员在基因组医学多学科团队和100,000个基因组项目中对中学发现的次要结果的观点
4. EmbedRF Position Tracking and Mobility Assessment System: A Low-power and Low-cost System for Passive Assessment of Patient Health in a Home Health-care Setting [C] . Peter G. Jacobs, Anindya S. Paul, Eric A. Wan International technical meeting of the Satellite Division of the Institute of Navigation;ION GNSS 2011 . 2011

机译：EmbedRF位置跟踪和移动性评估系统：一种用于家庭保健环境中患者健康状况被动评估的低功耗，低成本系统
5. Clinical outcomes and cost-effectiveness of white blood cell growth factors in elderly patients with non -Hodgkin's lymphoma: Findings from a large population-based cohort. [D] . Gruschkus, Stephen K. 2009

机译：非霍奇金淋巴瘤的老年患者的白细胞生长因子的临床结果和成本效益：基于大量人群的研究结果。
6. Secondary findings from clinical genomic sequencing: Prevalence patient perspectives family history assessment and healthcare costs from a multi-site study [O] . M. Ragan Hart, Barbara B. Biesecker, Carrie L. Blout, -1

机译：临床基因组测序的次要发现：多站点研究的患病率患者观点家族史评估和医疗保健费用
7. Correction: Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study [O] . M. Ragan Hart, Barbara B. Biesecker, Carrie L. Blout, 2019

机译：校正：来自临床基因组测序的二次结果：普遍存在，患病率，患者观点，家族历史评估以及多重研究中的医疗费用

Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study

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