Peptide-Based Delivery of Recombinant Proteins and Nucleic Acids:Using IntraStem to Deliver Therapeutics and Control Cell Fate

摘要

Successful regenerative medicine strategies often rely on exquisite control of the biological microenvironment and supplementation with extrinsic therapeutic molecules to direct cellular behavior.1,2 These macromolecules trigger intracellular signal transduction pathways, with complex cross-talk between the cascades and eventual programming of cell behaviour through transcription factors.2"' An issue with the strategy of delivering exogenous soluble factors to stimulate tissue regeneration is that they are often required at supraphysiological doses. This can cause many issues, ranging from cost of goods to dose-related side effects or overexuberant tissue formation.