The role of the carrier in the formulation of pharmaceutical solid dispersions. Part II: amorphous carriers

摘要

In 1965, Tachibana and Nakamura introduced a new method for the preparation of aqueous colloidal dispersions of (3-carotene by dissolving (3-carotene and polyvinylpyrrolidone (PVP) in chloroform followed by evaporation of the solvent, to obtain a P-carotene-PVP film [1]. This method was adopted by Mayersohn and Gibaldi in the subsequent year for production of solid solutions of ariseofulvin in PVP with dissolution rate of 5-10-fold higher than that of the micronized drug