Noninvasive assessment of H3 K27M mutational status in diffuse midline gliomas by using apparent diffusion coefficient measurements

Chen Hong; Hu Wanming; He Haoqiang; Yang Yuanzhong; Wen Ge; Lv Xiaofei

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Noninvasive assessment of H3 K27M mutational status in diffuse midline gliomas by using apparent diffusion coefficient measurements

机译：利用表观扩散系数测量，非诱导评价弥漫性中线胶质瘤的H3 k27m突变状态

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Purpose: H3 K27M-mutant diffuse midline gliomas are associated with worse prognosis than H3 K27M wild-type gliomas. In the present study, we sought to evaluate the conventional magnetic resonance imaging (cMRI) of H3 K27M-mutant glioma and examine whether diffusion-weighted imaging (DWI) derived apparent diffusion coefficient (ADC) could noninvasively predict H3 K27M mutational status in brain diffuse midline gliomas.

机译：目的：H3 K27M-突变体扩散中线胶质瘤与比H3 K27M野生型胶质瘤更差的预后相关。在本研究中，我们寻求评估H3 K27M-突变胶质瘤的常规磁共振成像（CMRI），并检查扩散加权成像（DWI）衍生的表观扩散系数（ADC）可以非侵入地预测脑弥漫性的H3 K27M突变状态中线胶质瘤。

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来源
《European Journal of Radiology》 |2019年第2019期|共8页
作者
Chen Hong; Hu Wanming; He Haoqiang; Yang Yuanzhong; Wen Ge; Lv Xiaofei;
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作者单位

Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med Dept Med Imaging State Key Lab Oncol;

Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med Dept Pathol State Key Lab Oncol South;

Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med Dept Med Imaging State Key Lab Oncol;

Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med Dept Pathol State Key Lab Oncol South;

Southern Med Univ Nanfang Hosp Dept Med Imaging Ctr Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med Dept Med Imaging State Key Lab Oncol;

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原文格式 PDF
正文语种 eng
中图分类放射医学;
关键词
Conventional MRI; Diffusion-weighted imaging; H3 K27M-mutant;

机译：常规MRI;扩散加权成像;H3 K27M-突变体;

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专利

1. Noninvasive assessment of H3 K27M mutational status in diffuse midline gliomas by using apparent diffusion coefficient measurements [J] . Chen Hong, Hu Wanming, He Haoqiang, European Journal of Radiology . 2019,第期

机译：利用表观扩散系数测量，非诱导评价弥漫性中线胶质瘤的H3 k27m突变状态
2. Diffuse Midline Gliomas without the H3 K27M Mutation: Surgical Biopsy is Needed to Better our Diagnostic Understanding [J] . World neurosurgery . 2020,第期

机译：没有H3 K27M突变的弥漫中线胶质瘤：需要手术活组织检查以更好地诊断理解
3. A case series of diffuse midline gliomas harboring H3 K27M mutation [J] . Barona Garcia L., Ferri Niguez B., Torroba Caron M. A., Virchows Archiv: an international journal of pathology . 2019,第Suppla1期

机译：涉及H3 K27M突变的案例系列弥漫性中线胶质瘤
4. Quantitative diffusion ??? Weighted imaging apparent diffusion coefficient values and perfusion ??? Weighted imaging relative cerebral blood volume in characterization of mixed gliomas (Grading II/III) [C] . Teodora-Anca Albu, Stanca-Mihaela Ple IEEE International Conference on E-Health and Bioengineering . 2015

机译：定量扩散加权成像表观扩散系数值和灌注混合脑胶质瘤表征中的加权成像相对脑血容量（II / III级）
5. Targeting the Disialoganglioside GD2 with Chimeric Antigen Receptor T Cells for Immunotherapy in Diffuse Midline Gliomas, and Exploration of Neuron-OPC Synaptic Connectivity in the Context of Adaptive Myelination [D] . Mount, Christopher W. 2020

机译：用嵌合抗原受体T细胞靶向Diaialoganglioside GD2，用于在弥漫性中线胶质瘤中的免疫疗法，以及在适应性髓鞘中的背景下探索神经元-Popaptic连通性
6. NIMG-71. DIFFUSION CHARACTERISTICS OF PEDIATRIC DIFFUSE MIDLINE GLIOMAS WITH HISTONE H3 K27M MUTATION USING APPARENT DIFFUSION COEFFICIENT HISTOGRAM ANALYSIS [O] . Mariam Aboian, David A Solomon, Cassie Kline-Nunnally, 2017

机译：NIMG-71。应用扩散系数直方图分析的组氨酸H3 K27M突变对小儿弥漫性中线胶质瘤的扩散特性
7. PDTM-04. REDEFINING THE CELLULAR ARCHITECTURE OF DIFFUSE MIDLINE GLIOMAS WITH H3 K27M MUTATIONS THROUGH LARGE-SCALE SINGLE-CELL ANALYSES [O] . Mariella Filbin, Itay Tirosh, Volker Hovestadt, 2017

机译：PDTM-04。通过大规模单细胞分析重新定义弥漫性中线胶质瘤的弥漫性中线胶质瘤的蜂窝结构

Noninvasive assessment of H3 K27M mutational status in diffuse midline gliomas by using apparent diffusion coefficient measurements

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