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首页> 外文期刊>European Journal of Haematology >Thrombotic microangiopathy with concomitant GI GI aGVHD after allogeneic hematopoietic stem cell transplantation: Risk factors and outcome
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Thrombotic microangiopathy with concomitant GI GI aGVHD after allogeneic hematopoietic stem cell transplantation: Risk factors and outcome

机译:异种造血干细胞移植后伴随综合GI GI AGVHD的血栓性微动病症:危险因素和结果

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摘要

Abstract Objectives To explore the possible risk factors for the occurrence and mortality of thrombotic microangiopathy ( TMA ) with concomitant acute graft‐vs‐host disease ( aGVHD ) and to investigate outcomes and treatments of this disorder after allo‐ HSCT . Methods Fifty cases diagnosed with TMA with concomitant aGVHD and 150 controls were identified from a cohort composed of 3992 patients who underwent allo‐ HSCT from 2008 to 2016. Results Grade III ‐ IV aGVHD ( P ?=?.000), acute kidney injury ( AKI ) ( P ?=?.033), and hypertension ( P ?=?.028) were significant independent risk factors associated with the occurrence of TMA with concomitant aGVHD . A haptoglobin level below normal ( P ?=?.013), a maximum volume of diarrhea 2500?mL/d ( P ?=?.015), and bloody diarrhea ( P ?=?.049) were significant markers for death in both univariate and multivariate analyses. Patients diagnosed with TMA with concomitant aGVHD had a lower overall survival (OS), a higher non‐relapse mortality ( NRM ), but a lower risk of relapse. Conclusions Thrombotic microangiopathy with concomitant aGVHD is a significant complication after allo‐ HSCT , with a worse outcome, including significantly lower OS and higher NRM . There are specific risk factors associated with occurrence and mortality of this complication.
机译:摘要目的,探讨致癌急性移植物与宿主疾病(AGVHD)的血栓形成微盲病(TMA)的可能性和死亡率的可能性因素,并在血清 - HSCT后调查这种疾病的结果和治疗。方法从2008年至2016年接受了3992名患者组成的队列组成的群组中,鉴定了具有伴随AGVHD和150个对照的TMA的50例。结果III级 - IV AGVHD(P?= ...... 000),急性肾损伤( aki)(p?= 033),高血压(p?=β.028)是与伴随agvhd的TMA发生相关的显着危险因素。低于正常的赤杆蛋白水平(p?= 013),最大体积的腹泻& 2500?ml / d(p?=β.015)和血性腹泻(p?=〜049)是重要的标记单变量和多变量分析中的死亡。患有伴随AGVHD的TMA患者的整体存活率下降(OS),较高的非复发死亡率(NRM),但复发风险较低。结论综合agvhd的血栓性微疗病是血栓溶膜后的显着并发症,具有较差的结果,包括显着降低的OS和更高的NRM。存在与这种并发症的发生和死亡率相关的特定风险因素。

著录项

  • 来源
    《European Journal of Haematology》 |2018年第2期|共11页
  • 作者单位

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

    Peking University People's HospitalPeking University Institute of HematologyBeijing China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 血液及淋巴系疾病;
  • 关键词

    acute graft‐vs‐host disease; allogeneic hematopoietic stem cell transplantation; thrombotic microangiopathy;

    机译:急性移植物与宿主疾病;同种异体造血干细胞移植;血栓形成微疗病;

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