methods of treating a human subject suffering from or at risk of developing graft versus host disease, diffuse alveolar hemorrhage and veno-occlusive disease and of treating, preventing or ameliorating one or more neurological symptoms associated with graft versus host disease or thrombotic microangiopathy associated with hematopoietic stem cell transplantation.

摘要

in one aspect, the invention provides methods of inhibiting the effects of masp-2 dependent complement activation in a human subject suffering from graft versus host disease and / or diffuse alveolar hemorrhage and / or veno-occlusive disease associated with a transplant. hematopoietic stem cell. the methods comprise the step of administering, to a subject in need thereof, an amount of a masp-2 inhibitory agent effective to inhibit masp-2 dependent complement activation.