Clinicopathological features of two cases of uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) and a comprehensive review of literature

摘要

Purpose: UTROSCTs are rare neoplasms of the uterine corpus. The authors report the clinicopathological characteristics of two cases of UTROSCTs and review the literature on these tumors. Materials and Methods: Medical records of two patients treated for an UTROSCT were analysed. A comprehensive review of literature was also performed. Results: Case 1: A 49-year old patient underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) for a suspected leiomyoma. The uterus contained leiomyomas and a 1.8-cm nodule diagnosed as an UTROSCT. Immunohistochemical analysis showed positivity for sex-cord and smooth muscle markers. Case 2: A 43-year-old patient underwent TAH-BSO for a uterine tumor adherent to the sigmoid serosa and pelvic peritoneum. Debulking surgery allowed complete cytoreduction. The pathologic analysis was compatible with UTROSCT. Cells stained for sex-cord and epithelial markers. Patient received adjuvant chemotherapy with bleomycin, etoposide, and cisplatin. Forty months after surgery, a three-cm UTROSCT lesion in the posterior cul-de-sac was surgically removed. Review of Literature: A review of the literature identified 85 cases of UTROSCTs. Hysterectomy is the gold standard therapy. More conservative surgery is an option for selected patients of childbearing age who wish to maintain their fertility potential. Recurrence or metastases are mainly addressed surgically. Conclusion: Due to the scarcity of published cases, there is little definite knowledge about UTROSCTs. UTROSCTs are of low malignant potential, thus long term follow-up is recommended.