C-Reactive Protein and Lipoprotein-Associated Phospholipase A_2 in Smokers and Nonsmokers of the Ludwigshafen Risk and Cardiovascular Health Study

摘要

Measurement of high sensitivity CRP (hsCRP) and lipoprotein-associated phospholipase A_2 (LpPLA_2) provides information on systemic inflammation and stability of atherosclerotic plaques. Data analyzing the effect of smoking on these parameters are sparse. The aim of our study was the analysis of these parameters in active smokers and never-smokers. The study included 777 smokers and 1,178 never-smokers, of whom 221 and 302 died during a follow-up, respectively. The values of LpPLAo and hsCRP were significantly higher in smokers than in never-smokers. Mortality was highest in smokers and never-smokers with elevation of both biomarkers.