超敏C反应蛋白和血尿酸及脂蛋白相关的磷脂酶A2与原发性高血压患者发生心血管事件的关系研究

摘要

ObjectiveTo investigate relationship between high-sensitivity C-reactive protein (hs-CRP), serum uric acid (SUA), lipoprotein-associated phospholipase A2 (LpPLA2) and cardiovascular event in essential hypertension patients.MethodsAmong a total of 216 patients with essential hypertension, 112 cases of them with cardiovascular event were taken as observation group, and the other 104 cases without cardiovascular event as control group. Their contents of hs-CRP, SUA, and LpPLA2 in peripheral blood were detected.ResultsThe observation group had much higher contents of hs-CRP, SUA, and LpPLA2 than the control group (P<0.01). Contents of hs-CRP, SUA, and LpPLA2 in the observation group were related with criticality of cardiovascular event. The higher contents would lead to higher criticality of cardiovascular event. The myocardial infarction group had obviously higher contents of hs-CRP, SUA, and LpPLA2 than the stenocardia group (P<0.01). ConclusionHigher contents of hs-CRP, SUA, and LpPLA2 will lead to higher criticality of cardiovascular event in essential hypertension patients.%目的：探讨超敏C反应蛋白(hs-CRP)、血尿酸(SUA)及脂蛋白相关的磷脂酶A2(LpPLA2)与原发性高血压患者心血管事件发生的关系。方法216例原发性高血压患者，其中发生心血管事件的112例为观察组，未发生心血管事件的104例为对照组。检测外周血hs-CRP、SUA、LpPLA2的含量。结果观察组hs-CRP、SUA及LpPLA2含量均明显高于对照组(P<0.01)；观察组中hs-CRP、SUA、LpPLA2的含量与心血管事件危险程度有关，其值越高，其发生心血管事件危险度越高。心肌梗死组中的hs-CRP、SUA、LpPLA2的含量明显高于心绞痛组(P<0.01)。结论 hs-CRP、SUA和LpPLA2的含量越高，原发性高血压患者发生心血管事件的风险可能性就越高。