Gut microbial functional maturation and succession during human early life

Cerdó Tomás; Ruiz Alicia; Acu?a Inmaculada; Jáuregui Ruy; Jehmlich Nico; Haange Sven‐Bastian; von Bergen Martin; Suárez Antonio; Campoy Cristina

摘要

Summary > The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health?later in life. Here, we combined cultivation‐independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full‐term healthy infants collected at 6 and 18 months of age. Phylogenetic analysis of the metaproteomes showed that Bifidobacterium provided the highest number of distinct protein groups. Considerable divergences between taxa abundance and protein phylogeny were observed at all taxonomic ranks. Age had a profound effect on early microbiota where compositional and functional diversity of less dissimilar communities increased with time. Comparisons of the relative abundances of proteins revealed the transition of taxon‐associated saccharolytic and fermentation strategies from milk and mucin‐derived monosaccharide catabolism feeding acetate/propanoate synthesis to complex food‐derived hexoses fuelling butanoate production. Furthermore, co‐occurrence network analysis uncovered two anti‐correlated modules of functional taxa. A low‐connected Bifidobacteriaceae ‐centred guild of facultative anaerobes was succeeded by a rich club of obligate anaerobes densely interconnected around Lachnospiraceae , underpinning their pivotal roles in microbial ecosystem assemblies. Our findings establish a framework to visualize whole microbial community metabolism and ecosystem succession dynamics, proposing opportunities for microbiota‐targeted health‐promoting strategies early in life. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>摘要</ title> >进化从出生的肠道微生物殖民化的轨迹已被证明是健康的素质？在生活中稍后。在此，我们组合培养的16S rRNA基因测序和标准组科，以研究粪便微生物在粪便样本中的肠道样品的功能成熟，从6岁和18个月收集的全长健康婴儿。元素的系统发育分析显示，双歧杆菌提供了最多的不同蛋白质基团。在所有分类法中观察到分类法和蛋白质发育之间的相当大的分歧。年龄对早期微生物群产生深远的影响，其中不相同的社区的组成和功能多样性随时间而增加。蛋白质的相对丰度的比较显示出牛奶和粘蛋白衍生的单糖分解代谢和丙烷合成的牛奶和丙蛋白衍生的单糖分解代谢转变为复杂的食物衍生的己烷促进丁醇酯生产。此外，共发生网络分析揭示了功能分类的两个反相关模块。低连接的 Bifidobacteriaceae </ i>兼容性厌氧的Centred anaerobes是由浓郁的厌氧菌的浓郁俱乐部成功，密集地互连，围绕 Lachnospheae致密连接，在微生物生态系统组件中支撑它们的枢转作用。我们的调查结果建立了一种可视化整个微生物群落新陈代谢和生态系统的继承动态的框架，提出了在生命期间早期的微生物群地点的健康促进策略的机会。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共18页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cerdó Tomás&option=202" target="_blank" rel="nofollow">Cerdó Tomás;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ruiz Alicia&option=202" target="_blank" rel="nofollow">Ruiz Alicia;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Acu?a Inmaculada&option=202" target="_blank" rel="nofollow">Acu?a Inmaculada;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jáuregui Ruy&option=202" target="_blank" rel="nofollow">Jáuregui Ruy;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jehmlich Nico&option=202" target="_blank" rel="nofollow">Jehmlich Nico;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Haange Sven‐Bastian&option=202" target="_blank" rel="nofollow">Haange Sven‐Bastian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=von Bergen Martin&option=202" target="_blank" rel="nofollow">von Bergen Martin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Suárez Antonio&option=202" target="_blank" rel="nofollow">Suárez Antonio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Campoy Cristina&option=202" target="_blank" rel="nofollow">Campoy Cristina;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Paediatrics School of MedicineUniversity of GranadaGranada Spain;</p> <p>EURISTIKOS Excellence Centre for Paediatric Research Biomedical Research Centre University of GranadaGranada Spain;</p> <p>Department of Biochemistry and Molecular Biology 2Biomedical Research Centre University of GranadaSpain;</p> <p>AgResearch Grasslands Tennent Drive Private Bag 11008Palmerston North New Zealand;</p> <p>Department of Molecular System BiologyHelmholtz Centre for Environmental Research‐ UFZ Permoserstra?e 15Leipzig Germany;</p> <p>Department of Molecular System BiologyHelmholtz Centre for Environmental Research‐ UFZ Permoserstra?e 15Leipzig Germany;</p> <p>Department of Molecular System BiologyHelmholtz Centre for Environmental Research‐ UFZ Permoserstra?e 15Leipzig Germany;</p> <p>Department of Biochemistry and Molecular Biology 2Biomedical Research Centre University of GranadaSpain;</p> <p>Department of Paediatrics School of MedicineUniversity of GranadaGranada Spain;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" 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class="tuijian_auth tuijian_authcolor">,胡金芝</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴岸敏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴岸敏</a> <span> <a href="/journal-cn-6722/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国现代医生 </a> </span> <span> . 2019</span><span>,第025期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-24325_thesis/020221109749.html">肠道微生物研究:从组成到功能——肠道健康功能微生物的研究进展</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱伟云&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 朱伟云</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=姚文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,姚文</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=毛胜勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,毛胜勇</a> <span> <a href="/conference-cn-24325/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国畜牧兽医学会动物微生态学分会第三届第八次全国学术研讨会暨动物微生态企业发展战略论坛 </a> <span> <span> . 2006</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312825654.html">生命早期不同环境微生物暴露对小鼠肠道菌群与哮喘的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=金雯&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 金雯</a> <span> . 2018</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120101537481.html">环境水体中人类肠道病毒与非人类肠道病毒含量检测方法</a> <b>[P]</b> . <span> 中国专利： CN102888469A </span> <span> . 2013-01-23</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120113978106.html">影响人类肠道微生物的组合物和方法</a> <b>[P]</b> . <span> 中国专利： CN114072071A </span> <span> . 2022-02-18</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130406771175.html">human isolated, synthetic or recombinant antibody, or a functional part or a functional equivalent thereof, isolated, synthetic or recombinant nucleic acid molecule, vector, isolated or recombinant cell or non-human animal, composition, use of an antibody or functional part or functional equivalent, and methods for producing an antibody or functional part or functional equivalent, for detecting myeloproliferative or lymphoproliferative cells, for determining whether a myeloid or lymphoid cell is a myeloproliferative or lymphoproliferative cell, for identifying myeloproliferative or lymphoproliferative cells, for To determine whether myeloproliferative or lymphoproliferative cells are present in a sample to treat and / or prevent a myeloproliferative or lymphoproliferative disorder, to determine whether an individual suffers from a myeloproliferative or lymphoproliferative disorder to typify a sample containing m cell. or a lymphoid cell-containing sample from an individual, and, to det</a> <b>[P]</b> . <span> 外国专利：  BR112016014072A2 </span> <span> . 2018-01-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人类分离的，合成的或重组的抗体或其功能部分或功能等同物，分离的，合成的或重组的核酸分子，载体，分离的或重组的细胞或非人类动物，抗体的组成，用途或功能部分等同物，以及产生抗体或功能性部分或功能等同物的方法，用于检测骨髓增生性或淋巴增生性细胞，确定髓样或淋巴增生性细胞是骨髓增生性或淋巴增生性细胞，鉴定骨髓增生性或淋巴增生性细胞，以确定骨髓增生性或淋巴细胞增生性样品中存在淋巴增生细胞，以治疗和/或预防骨髓增生性或淋巴增生性疾病，以确定个体是否患有骨髓增生性或淋巴增生性疾病，以代表包含m细胞的样品。或来自个体的含有淋巴样细胞的样本，并且 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130400685510.html">Composition for Imitative Culturing Human Gut Microbiota Imitative Culture Method of Human Gut Microbiota using the Anaerobic Cultivation System Microbial Agent by Manufactured thereof and Use thereof</a> <b>[P]</b> . <span> 外国专利：  KR20200106439A </span> <span> . 2020-09-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于模拟培养人类肠道菌群的组合物及其制造方法及其使用厌氧培养系统微生物剂的模拟培养人类肠道菌群的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130400860678.html">COMPOSITION FOR CULTURING HUMAN GUT MICROBIOME MIMIC, METHOD FOR CULTURING HUMAN GUT MICROBIOME MIMIC BY USING ANAEROBIC CULTURE SYSTEM, MICROBIAL AGENT PREPARED THEREBY, AND USE THEREOF</a> <b>[P]</b> . <span> 外国专利：  WO2020180037A1 </span> <span> . 2020-09-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于培养人类肠道微生物组的组合物，使用厌氧培养系统培养人类肠道微生物组的方法，由此制备的微生物制剂及其用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 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