Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6‐Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk

Saad Ahmed Sayed; Alamein Amal Mahmoud Abou Al; Galal Maha Mohammed; Zaazaa Hala Elsayed

摘要

Abstract > Sustainable chemistry has attracted the attention of scientists during the last decades owing to the great advantages encountered by its application. These include: waste reduction, energy conservation and substitution of hazardous substances with more eco‐friendly ones. Following this approach, a new sensitive and selective membrane sensor was developed and investigated for the determination of lidocaine hydrochloride (LD) and its carcinogenic metabolite 2,6‐dimethylaniline (DMA). Several polyvinyl chloride (PVC) based sensors were tried using different plasticizers as well as different cation exchangers. The best response was achieved upon using dioctylphthalate (DOP) as solvent mediator and phosphotungstate (PT) as cation exchanger. LD was selectively determined at pH?6 without interference from its carcinogenic metabolite, while DMA that had been reported to be the toxic inactive metabolite of LD secreted in the milk was determined in the milk at pH?2. Fast, stable Nernstian responses were achieved by the proposed sensors over a concentration range of 2.66×10 ?5 ?M to 1×10 ?2 ?M for both LD and DMA. The method was validated according to the IUPAC recommendations and was successfully applied for the determination of LD in pure form and pharmaceutical dosage form, whereas DMA was successfully determined in pure form and spiked milk samples. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >可持续化学在过去几十年中，由于遇到的良好优势，在过去几十年中引起了科学家的注意它的应用。这些包括：减少减少，节能和含有更环保的物质的节能和替代危险物质。在这种方法之后，开发并研究了一种新的敏感和选择性膜传感器，用于测定利多卡因盐酸盐（LD）及其致癌代谢物2,6-二甲基苯胺（DMA）。使用不同的增塑剂以及不同的阳离子交换剂尝试了几种基于聚氯乙烯（PVC）的传感器。使用二辛酰苯二甲酸酯（DOP）作为溶剂介体和磷钨酸盐（Pt）作为阳离子交换剂进行最佳反应。在pHα6中选择性地测定LD而不从其致癌代谢物干扰，而据报道的DMA是在牛奶中在pH？2的牛奶中测定牛奶中的LD的有毒活性代谢物。在LD和DMA的浓度范围内，所提出的传感器通过2.66×10 5 </ sup>Δm至1×10 Δ2</ sup>Δm的浓度范围内实现的稳定性稳定的响应。。该方法根据IUPAC建议进行验证，并成功地应用于纯形式和药物剂型中LD的测定，而DMA以纯的形式成功测定并掺入牛奶样品。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Saad Ahmed Sayed&option=202" target="_blank" rel="nofollow">Saad Ahmed Sayed;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alamein Amal Mahmoud Abou Al&option=202" target="_blank" rel="nofollow">Alamein Amal Mahmoud Abou Al;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Galal Maha Mohammed&option=202" target="_blank" rel="nofollow">Galal Maha Mohammed;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zaazaa Hala Elsayed&option=202" target="_blank" rel="nofollow">Zaazaa Hala Elsayed;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Analytical Chemistry Department Faculty of PharmacyCairo UniversityKasr El Aini st. 11562- Cairo Egypt;</p> <p>Analytical Chemistry Department Faculty of PharmacyCairo UniversityKasr El Aini st. 11562- Cairo Egypt;</p> <p>Analytical Chemistry Department Faculty of PharmacyCairo UniversityKasr El Aini st. 11562- Cairo Egypt;</p> <p>Analytical Chemistry Department Faculty of PharmacyCairo UniversityKasr El Aini st. 11562- Cairo Egypt;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Green chemistry&option=203" rel="nofollow">Green chemistry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lidocaine hydrochloride&option=203" rel="nofollow">Lidocaine hydrochloride;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dimethylaniline&option=203" rel="nofollow">Dimethylaniline;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Phosphotungstate&option=203" rel="nofollow">Phosphotungstate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ion selective electrodes&option=203" rel="nofollow">Ion selective electrodes;</a> </p> <div class="translation"> 机译：绿色化学;Lidocaine盐酸盐;二甲基苯胺;磷钨酸盐;离子选择性电极; 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target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 焦亚奇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王九成&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王九成</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冯会迎&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,冯会迎</a> <span> <a href="/journal-cn-56853/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国医药工业杂志 </a> </span> <span> . 2003</span><span>,第9期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-2134_thesis/02022404269.html">气相色谱-质谱法测定牛奶中的双甲脒及其代谢物残留量</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lv Jianxia&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Lv Jianxia</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吕建霞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吕建霞</a> <span> <a href="/conference-cn-2134/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2014第三届环渤海色谱质谱学术报告会 </a> <span> <span> . 2014</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120103777793.html">一种不加额外碱的制备利多卡因中间体α-氯乙酰-2,6-二甲基苯胺和利多卡因的方法</a> <b>[P]</b> . <span> 中国专利： CN111253273A </span> <span> . 2020-06-09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130411309901.html">GEL include nifedipine and lidocaine hydrochloride (RU) Application of gel containing lidocaine hydrochloride and nifedipine (RU) METHOD FOR PREPARING gel containing lidocaine hydrochloride and nifedipine using nanotechnology</a> <b>[P]</b> . <span> 外国专利：  RU2015103157A </span> <span> . 2016-08-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：GEL包括硝苯地平和盐酸利多卡因（RU）含有盐酸利多卡因和硝苯地平（RU）的凝胶的应用纳米技术制备含有盐酸利多卡因和硝苯地平的凝胶的方法 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130437788093.html">PROCESS FOR PREPARING OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE AND OXYCODONE HYDROCHLORIDE COMPOSITION,PHARMACEUTICAL DOSAGE FORM,SUSTAINED RELEASE ORAL DOSAGE FORM AND PHARMACEUTICALLY ACCEPTABLE PACKAGE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE</a> <b>[P]</b> . <span> 外国专利：  CL2005000701A1 </span> <span> . 2006-01-20</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：制备小于25 PPM的羟考酮的方法14-羟可待因酮和羟考酮的组成，药物剂量形式，持续释放的口服剂量形式和药理可服用的25包粉盒包装 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130427922384.html">rimonabant hydrochloride, process for the preparation of a rimonabant hydrochloride, pharmaceutical composition, pharmaceutical dosage form, use of a rimonabant hydrochloride and method of treatment</a> <b>[P]</b> . <span> 外国专利：  BRPI0606199A2 </span> <span> . 2009-11-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：盐酸利莫那班，盐酸利莫那班的制备方法，药物组合物，药物剂型，盐酸利莫那班的用途和治疗方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" 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