...
首页> 外文期刊>International journal of surgical pathology >Primary Central Nervous System T-Cell Lymphoma With Aberrant Expression of CD20 and CD79a: A Diagnostic Pitfall
【24h】

Primary Central Nervous System T-Cell Lymphoma With Aberrant Expression of CD20 and CD79a: A Diagnostic Pitfall

机译:中枢神经系统T细胞淋巴瘤,具有多种CD20和CD79a的表达:诊断陷阱

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

Primary central nervous system T-cell lymphoma (PCNSTCL) is rare, accounting for 2% of CNS lymphomas. We report the first case of PCNSTCL with aberrant expression of CD20 and CD79a in an 81-year-old man with a left periventricular brain mass. A biopsy revealed dense lymphoid infiltrate consisting of medium-sized cells in a background of gliosis and many histiocytes. The lymphoid cells were positive for CD2, CD3, CD7, CD8, T-cell intracellular antigen-1, granzyme B, CD20, and CD79a and negative for CD4, CD5, PAX-5, OCT-2, BOB-1, human herpes virus-8, and Epstein-Barr virus-encoded small RNAs. Molecular studies revealed clonal TCR- and TCR- gene rearrangements and negative immunoglobulin gene rearrangements. The patient was treated with chemotherapy (vincristine and methotrexate) and rituximab, but he died 1 month after the diagnosis. This is a unique case that emphasizes the use of a multimodal approach, including a broad immunohistochemical panel and molecular studies in lineage determination for lymphomas with ambiguous phenotype.
机译:初级中枢神经系统T细胞淋巴瘤(PCNSTCL)很少见,占CNS淋巴瘤的2%。我们在一个81岁的男子中报告了第一种PCNSTCL在一个81岁男性中的CD20和CD79a的异常表达,左侧脑质量。活检显示胶质症和许多组织细胞的中等细胞组成的致密淋巴渗透。淋巴细胞为CD2,CD3,CD7,CD8,T细胞细胞内抗原-1,Granzyyme B,CD20和CD79a阳性,CD4,CD5,PAX-5,OCT-2,BOB-1,人疱疹阴性病毒-8和Epstein-Barr病毒编码的小RNA。分子研究揭示了克隆TCR和TCR-基因重排和阴性免疫球蛋白基因重排。患者用化疗(甲羟肟和甲氨蝶呤)和Rituximab治疗,但他在诊断后1个月死亡。这是一种独特的案例,强调使用多式联理方法,包括宽免疫组织化学板和血管型测定的分子研究,淋巴瘤具有含糊不清的表型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号