Inadequate oxygenation of the eye perturbs retinal function and processes, and can lead to vision loss. The difference in oxygen saturation between the retinal arteries and veins correlates with oxygen metabolism. When light interacts with the retina, spectral reflectance conveys information about the state and composition of retinal tissue, including oxygen saturation. Light has been used to estimate oxygen saturation levels noninvasively based on the unique spectral signatures of oxyhemoglobin and deoxyhemoglobin in the retinal blood vessels. Notable publications in the past have acquired oximetry data using only 2- or 3-wavelength measurements of the eye.
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