Bio-hybrid acrylic hydrogels containing metronidazole - loaded poly(acrylic acid-co-methyl methacrylate) nanoparticles and Aloe vera as natural healing agent

摘要

In this work we present the preparation route of acrylic hydrogels containing metronidazole - loaded poly(acrylic acid-co-methyl methacrylate) micro- and nanoparticles and Aloe vera. In these bio-hybrid materials the bactericidal activity of metronidazole will allow considerably better treatment of infections and Aloe vera will moisturize the skin and accelerate the regeneration processes. The structure of the prepared hydrogels was analyzed using FT-IR, whereby the surface morphology was characterized using SEM - EDS. The obtained materials were studied for swelling behavior and biological properties in water and simulated body fluids. Moreover, the thermal stability was ascertained using TG and DSC.