Method for preparing nanoparticles comprising vitamin K and poly-isopropyl-butyl methacrylate-acrylic acid copolymer with supercritical fluid using molecular association theory

摘要

The present invention relates to a method for preparing supercritical nanoparticles of vitamin K by a supercritical fluid process.;The basic concept of the preparation method is as follows. A nanoscaled vitamin K complex is prepared by dissolving vitamin K and a biodegradable polymer in a suitable amount of an organic solvent, spraying the solution into a reactor equilibrated with a supercritical carbon dioxide via a nozzle to obtain particles, introducing supercritical carbon dioxide several times to the particles, extracting the organic solvent out, and then removing carbon dioxide.