Development of interpenetrating polymeric network for controlled drug delivery and its evaluation

摘要

Polymers play vital role in drug delivery systems. Aim of current research work was to elucidate the effect of Hydroxyethyl cellulose (HEC), acrylic acid (AA) and N'N'-methylene bis-acrylamide (MBA) in formulation of pH sensitive nexus for targeted delivery of acid sensitive drug perindopril erbumine (PE). Different feed ratios were employed to prepare nexus via free radical polymerization. FTIR (Fourier transform infrared spectroscopy) depicts efficient grafting. Thermal parameters (DSC, DTA and TGA) were thermodynamically stable and morphological (SEM) analysis represented porous architecture. pH sensitivity was supported by on-off switching in acid and basic media. Hence, HEC-co-AA based design was encouraging for targeted delivery of perindopril erbumine.