Meta‐regression analysis to evaluate relationships between maternal blood levels of placentation biomarkers and low delivery weight

摘要

Abstract Background Caution is required for women at increased risk of low neonatal delivery?weight. Objective To evaluate relationships between maternal placentation biomarkers and the odds of low delivery weight. Search strategy Databases including PubMed/ MEDLINE were searched up to May 2017 using keywords involving biomarker names and “low birthweight.” Selection criteria English language studies providing true‐ and false‐positive, and true‐ and false‐negative results of low delivery weight classified by maternal blood levels of placentation biomarkers (in units of multiple of the mean [MoM]) were included. Data collection and analysis Coefficients representing changes in log odds ratio for low delivery weight per 1 MoM increase in maternal blood placentation biomarkers, and those adjusted for race, sampling period, and/or study quality were calculated. Main results Adjusted coefficients representing changes in log odds ratio for low delivery weight per 1 MoM increase in maternal blood levels of α‐fetoprotein ( AFP ) and β‐human chorionic gonadotropin (β‐ hCG ) were significantly greater than 0 (both P 0.001), whereas that for pregnancy‐associated plasma protein A ( PAPP ‐A) was significantly less than 0 ( P =0.028). Adjusted models explained the higher proportion of between‐study variance better than non‐adjusted models. Conclusions Elevated AFP and β‐ hCG , and reduced PAPP ‐A in maternal blood were positively associated with odds of low delivery weight.