Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

摘要

Abstract Objective To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome ( PCOS ) among non‐obese women. Methods A prospective observational cross‐sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non‐obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non‐obese normo‐ovulatory women without signs of PCOS (control group; n=44). Anthropometric variables related to metabolic profile were determined. Laboratory measures were assessed using fasting blood samples. Results Waist circumference and waist‐to‐hip ratio were increased among women with PCOS (both P ?0.001). When compared with the control group, patients in the PCOS group exhibited increases in cholesterol (13.8%), triglycerides (36.6%), low‐density lipoprotein (73.2%), fasting glucose (9.2%), fasting insulin (49.4%), luteinizing‐hormone/follicle‐stimulating‐hormone ratio (205.3%), 17β‐estradiol (39.2%), testosterone (202.3%), and vascular endothelial growth factor (241.7%) (all P 0.001); and decreases in high‐density lipoprotein (?25.3%), progesterone (?7.4%), and sex hormone‐binding globulin (?54.0%) (all P 0.001). Vitamin D ( P =0.095) and Kisspeptin ( P =0.944) levels did not differ between the groups. Conclusion Various parameters could potentially be used as biomarkers to assess risk of PCOS , even among symptom‐free non‐obese women.