Aerobic exercise regulating expression of ER alpha and ER beta in prostate to prevent benign prostatic hyperplasia of obesity mice

摘要

High-fat-diet (HFD) induced BPH mice model used to examine how aerobics exercise prevents the development of BPH and try to find the mechanism. Materials and Methods: C57BL/6J mice were randomized into three groups for a 6-week intervention: Control group (Co, n = 8) and Diet group (Di, n = 8) fed standard diet, and Exercise and diet group fed standard diet meanwhile run on a treadmill at 12m/min, 30 min/day, 6 days/week (Ex+Di, n = 8). Body weight (BW), fat, prostate weight (PW), prostate index (PI), Estradio(E-2), Testosterona (T) and estrogen receptor(ER) were detected. Results: The Di had a higher BW, fat, PW and PI, compared to Co and Ex+Di. BW and PI in Ex+Di significantly lower compared to Di, thus running prevented increase in BW and PI. Although, E2 and T in Di and Ex+Di haven't seen anything statistically significant, compared with Co. However, ER alpha in Ex+Di (0.039 +/- 0.012 ng/ml) was significant reduced (P<0.05) compared with Di (0.046 +/- 0.011 ng/ml); Compared with Di (0.032 +/- 0.009 ng/ml), ER beta in Ex+Di (0.039 +/- 0.011 ng/ml) was significant reduced (P<0.05). Conclusion: Obesity is an important risk factor for the development of BPH. It may also provide scientific evidence to promote weight loss and aerobic exercise beneficial adjuvant therapies for BPH.