Expression of MMP-9 and hs-CRP in the serum of patients with viral myocarditis

摘要

Objective: This study was designed to evaluate the expression of high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase (MMP-9) in patients with viral myocarditis (VM), and its clinical significance. Methods: A total of 126 patients with VM admitted to our hospital were included as the study subjects, placed into the observation group and compared with 120 healthy objects who received physical examination in our hospital in the same period as the control group. To test hs-CRP and MMP-9 in both groups, particle-enhanced turbidimetric immunoassay (PETIA) and enzyme linked immunosorbent assay (ELISA) were adopted, respectively. The two groups were compared for the expression of hs-CRP and MMP-9 in serum and the positive rate. Results: (1) In the observation group, the main symptoms in the 126 patients with VM included 92 with fever, 8 with hidrosis, 3 with shortness of breath, 50 with nausea and vomiting, 48 with discomfort of the precordial area, 43 with general fatigue, 100 with abdominal pain, and 32 with expiratory dyspnea. (2) In the observation group, the main signs in the patients with VM included 126 with a low and obtuse first heart sound (S1), 92 with arrhythmia, 95 had sychnosphygmia, 12 with bradycardia, 45 with proiosystole and 3 with shock. (3) In the observation group, the hs-CRP and MMP-9 positive rates were 84.13% and 92.06%, and the measured hs-CRP and MMP-9 were (12.42 +/- 3.45) mg/L and (39.89 +/- 5.68) mu g/L, respectively; while those of in the control group were 3.33%, 8.33%, (1.81 +/- 0.18) mg/L, and (28.02 +/- 1.28) mu g/L, respectively: which were significantly different (P<0.05). Conclusion: Patients with VM have markedly elevated hs-CRP and MMP-9 in their serum, which can be used as important auxiliary indices in the clinical diagnosis of VM.