Prevalence of Subclinical Hypothyroidism in Pregnancy & Its Impact on Feto-Maternal Outcome

摘要

Objective: To evaluate the prevalence of subclinical hypothyroidism in pregnancy and its impact on feto maternal outcomes.Method:The prospective study was conducted on 566 no of antenatal women. Complete thyroid profile was done and they were divided in two groups. Those with subclinical hypothyroidism [raised serum TSH & normal FT3,FT4](n=30) constructed the study group and the rest were the control group (n=536).Both the groups were comparedin terms of maternal and fetal outcomes. Results: The prevalence of subclinicat hypothyroidism(SCH) was calculated to be 5.3%. There was an increased risk for abruptio placentae (9 times)& preterm delivery(6times) in subclinical hypothyroidism. Also there was increased rate of LSCS due to fetal distress(43%) in the cases with SCH . Adverse fetal outcomes include low birth weight,poor APGAR score and increased NICU admission. Cord blood TSH was raised in 6% of subclinical hypothyroid patients.Conclusion: subclinical hypothyroidism is associated with various pregnancy complications and poor perinatal outcomes, This study reveals the adverse clinical manifestation and benefits of treatment, justifying the need of screening for thyroid function in early pregnancy.