SYNTHESIS AND IN VITRO ANTIMYCOBACTERIAL ACTIVITY OF 7-[3-(SUBSTITUTED) PHENYLPROP-2-ENOYL]-2,3-DIPHENYL-5H,10H-BENZO[g] QUINOXALINE-5,10-DIONES

摘要

Eleven new compounds diones namely, 7-[3-(substituted) phenylprop-2-enoyl]-2,3-diphenyl-5H, 10H-benzo[g] quinoxaline-5,10-dione (6a-k) were synthesized by multistep synthetic scheme. The newly synthesized compounds were submitted for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv by L. J. Slope (Conventional) Method. Compound 6e having 4-OCH3 at phenyl ring attached to 3-position of prop-2-enoyl group has been observed as the most active antimycobacterial compound, while compound 6h having 4-CF3 group on the above-mentioned position has been observed as the least active antimycobacterial compound of the newly synthesized series.