where X - halogen or trifluoromethanesulfonyl- -hydroxy-group; NR1R2, wherein R1 - hydrogen - methyl; R3 - hydrogen, C1-8-alkyl, C6-10-aryl possibly substituted with hydroxy-group or halogen; R4 - H, C1-6-alkyl; W - amino-group monosubstituted with C1-12-alkyl with a substitute indicated in p. 1 of an invention. Compounds of the formula (I) show antibiotic activity against broad spectrum of organisms including that showing resistance to tetracyclines and they are useful as antibiotics. EFFECT: new compounds, improved method of synthesis. 11 cl, 3 dwg, 1 tbl, 76 ex"/>
NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-(SUBSTITUTED-GLYCYL)- -AMIDO-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY
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NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-(SUBSTITUTED-GLYCYL)- -AMIDO-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY
NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-(SUBSTITUTED-GLYCYL)- -AMIDO-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY
FIELD: organic chemistry. SUBSTANCE: invention relates to new 1,11-dioxo-2-naphthacene carboxamides of the formula (I) where X - halogen or trifluoromethanesulfonyl- -hydroxy-group; NR1R2, wherein R1 - hydrogen - methyl; R3 - hydrogen, C1-8-alkyl, C6-10-aryl possibly substituted with hydroxy-group or halogen; R4 - H, C1-6-alkyl; W - amino-group monosubstituted with C1-12-alkyl with a substitute indicated in p. 1 of an invention. Compounds of the formula (I) show antibiotic activity against broad spectrum of organisms including that showing resistance to tetracyclines and they are useful as antibiotics. EFFECT: new compounds, improved method of synthesis. 11 cl, 3 dwg, 1 tbl, 76 ex
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机译：领域：有机化学。物质：本发明涉及式（I）的新的1,11-二氧-2-萘并苯甲酰胺<图像文件=“ 00000002.GIF” he =“ 35” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 75 “ X-卤素或三氟甲磺酰基-羟基; NR 1 R 2 ，其中R 1 -氢-甲基; R 3 -氢，C 1-8 -烷基，C 6-10 -芳基，可能被羟基或卤素取代; R 4 -H，C 1-6 -烷基; W-用C 1-12 -烷基单取代的氨基，其取代基在p中表示。发明的图1。式（I）化合物显示出对广谱生物的抗生素活性，包括对四环素具有抗性的化合物，它们可用作抗生素。效果：新化合物，改进的合成方法。 11厘升，3桶，1桶，76桶
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