Removal of some commonly used protecting groups in peptide syntheses by catalytic transfer hydrogenation with formic acid and 10% palladium on carbon

摘要

It is shown that HCOOH, a good solvent for most peptides, can be conveniently used as a hydrogen donor for catalytic transfer hydrogenation with less expensive 10% Pd on C when compared to palladium black. The protecting groups that are being successively removed include the N~(#alpha#)-benzyloxycarbonyl, N~(#epsilon#)-2-chlorobenzyloxycarbonyl, C-terminal benzyl ester, O-benzyl ether of O-benzyltyrosine, serine or threonine, nitro of nitroarginine and N~(im)-benzyloxymethyl of histidine.