Authors' response to: Statins in pregnancy: Safety and perspectives of therapeutic applications

摘要

We thank Dr Vlachadis and colleagues for their interest in our work and their comments, The results of our study, which showed no significant increase in the risk of major birth defects after statin exposure during the first trimester of pregnancy, incited them to argue in favour of the future use of statins in the prevention of pre-eclampsia and other obstetric complications.We agree upon theoretical considerations and experimental data possibly supporting the idea that statins could be useful in the prevention of pre-eclampsia; however, these mechanistic arguments have, as yet, not been supported by clinical evidence.