[067] IN SILICO/COMPUTATIONAL MODELING EFFORTS TO MITIGATE AEROTOXIC SYNDROME

摘要

INTRODUCTION: The 711th Human Performance Wing conducted a study to investigate the etiology of reported respiratory symptoms and alleviate one of the most common health-related complaints of high-performance aircraft flight. This study found a positive statistical association between respiratory effects and a short list of potentially toxic chemicals. To better extrapolate in-flight exposure of pilots to compounds and improve aerotoxic syndrome mitigation, physiologically based pharmacokinetic (PBPK) and quantitative structure activity relationship (QSAR) in silico modeling tools have been employed. METHODS: PBPK is a mathematical modeling technique for predicting the absorption, distribution, metabolism, and excretion of chemical substances in humans.