Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

Mistry Pragnesh; Carmona-Rivera Carmelo; Ombrello Amanda K.; Hoffmann Patrycja; Seto Nickie L.; Jones Anne; Stone Deborah L.; Naz Faiza; Carlucci Philip; DellOrso Stefania; Gutierrez-Cruz Gustavo; Sun Hong-Wei; Kastner Daniel L.; Aksentijevich Ivona; Kaplan Mariana J.

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Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

机译：爸爸综合征的失调中性粒细胞反应和中性粒细胞细胞外陷阱形成和降解

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Objectives Pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome is characterised by flares of sterile arthritis with neutrophil infiltrate and the overproduction of interleukin (IL)-1 beta. The purpose of this study was to elucidate the potential role of neutrophil subsets and neutrophil extracellular traps (NET) in the pathogenesis of PAPA.

机译：目的性关节炎，Pyoderma gangrenosum和痤疮（爸爸）综合征的特征在于无菌关节炎，中性粒细胞浸润和白细胞介素（IL）-1β的过度生产。本研究的目的是阐明中性粒细胞亚群和中性粒细胞细胞外疏水阀（净）在爸爸发病机制中的潜在作用。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2018年第12期|共9页
作者
Mistry Pragnesh; Carmona-Rivera Carmelo; Ombrello Amanda K.; Hoffmann Patrycja; Seto Nickie L.; Jones Anne; Stone Deborah L.; Naz Faiza; Carlucci Philip; DellOrso Stefania; Gutierrez-Cruz Gustavo; Sun Hong-Wei; Kastner Daniel L.; Aksentijevich Ivona; Kaplan Mariana J.;
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作者单位

Natl Inst Arthrit &

Musculoskeletal &

Skin Dis NI Syst Autoimmun Branch NIH Bethesda MD 20892;

Natl Inst Arthrit &

Musculoskeletal &

Skin Dis NI Syst Autoimmun Branch NIH Bethesda MD 20892;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

Natl Inst Arthrit &

Musculoskeletal &

Skin Dis NI Syst Autoimmun Branch NIH Bethesda MD 20892;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

NIAMS Lab Muscle Stem Cells &

Gene Regulat NIH Bethesda MD USA;

Natl Inst Arthrit &

Musculoskeletal &

Skin Dis NI Syst Autoimmun Branch NIH Bethesda MD 20892;

NIAMS Lab Muscle Stem Cells &

Gene Regulat NIH Bethesda MD USA;

NIAMS Lab Muscle Stem Cells &

Gene Regulat NIH Bethesda MD USA;

NIAMS Biodata Min &

Discovery Sect NIH Bethesda MD USA;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

NHGRI Inflammatory Dis Sect NIH Bethesda MD 20892 USA;

Natl Inst Arthrit &

Musculoskeletal &

Skin Dis NI Syst Autoimmun Branch NIH Bethesda MD 20892;

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正文语种 eng
中图分类免疫性疾病;
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1. Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome [J] . Mistry Pragnesh, Carmona-Rivera Carmelo, Ombrello Amanda K., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第12期

机译：爸爸综合征的失调中性粒细胞反应和中性粒细胞细胞外陷阱形成和降解
2. Candida albicans enolase interacts with neutrophil proteins involved in the formation of neutrophil extracellular traps in response to candidial infections. [J] . Seweryn K., Zawrotniak M., Bochenska O., The FEBS journal . 2014,第Suppla1期

机译：白色念珠菌烯醇化酶与参与念珠菌感染的嗜中性白细胞蛋白相互作用，该蛋白与嗜中性白细胞胞外陷阱的形成有关。
3. Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis [J] . Yoshida Masaharu, Yamada Muneharu, Sudo Yasuyo, Nephrology. . 2016,第7期

机译：髓过氧化物酶抗中性粒细胞胞浆抗体亲和力与肾脏中性粒细胞外陷阱的形成和血管炎相关，与髓过氧化物酶抗中性粒细胞胞浆抗体相关的显微多血管炎
4. Neutrophil Extracellular Traps (NETs): An unexplored territory in renal pathobiology, a pilot computational study [C] . Briana A. Santo, Brahm H. Segal, John E. Tomaszewski, Conference on Medical Imaging: Digital Pathology . 2020

机译：中性粒细胞外细胞疏水阀（网）：肾病学的未开发领土，试点计算研究
5. Rac2 is Required for Formation of Extracellular Traps in Neutrophils [D] . Lim, Byung Hyun Michael 2011

机译：Rac2是嗜中性粒细胞形成细胞外陷阱所必需的
6. Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils Neutrophil Extracellular Trap (NET) Formation and NET Degradation [O] . Meraj A. Khan, Zubair Sabz Ali, Neil Sweezey, 2019

机译：囊性纤维化肺疾病从儿童期到成年期的进展：中性粒细胞中性粒细胞胞外陷阱（NET）的形成和NET的降解
7. Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome [O] . Pragnesh Mistry, Carmelo Carmona-Rivera, Amanda K Ombrello, 2018

机译：爸爸综合征的失调中性粒细胞应答和中性粒细胞外阱形成和降解

Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome

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