Synthesis of Chiral Aza-[n.2.1] Skeletons by Separable Epimers of Intramolecular [3+2] Cross Cycloaddition of Cyclopropane 1,1-Diesters with Chiral Sulfinylimines

摘要

Reported herein is the construction of chiral aza-[n.2.1] skeletons by separable epimers of intramolecular [3+2] cross cycloaddition of cyclopropane 1,1-diesters with chiral sulfinylimines. The epimer products can be separated by silica gel column chromatography.