COMBINED ANGIOTENSIN II TYPE-1 RECEPTOR BLOCKADE AND SUPEROXIDE ANION SCAVENGING AFFECT THE POST-ISCHEMIC KIDNEY IN HYPERTENSIVE RATS

Ivanov Milan; Mihailovic-Stanojevic Nevena; Markovic-Lipkovski Jasmina; Jovovic Durdica; Karanovic Danijela; Miloradovic Zoran; Jelica Grujic-Milanovic

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COMBINED ANGIOTENSIN II TYPE-1 RECEPTOR BLOCKADE AND SUPEROXIDE ANION SCAVENGING AFFECT THE POST-ISCHEMIC KIDNEY IN HYPERTENSIVE RATS

机译：联合血管紧张素Ⅱ1型受体阻滞剂和过氧化物阴离子消除对高血压大鼠缺血后肾脏的影响

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Ischemic acute kidney injury is characterized by renal vasoconstriction, filtration failure, tubular obstruction, tubular backleak and overproduction of angiotensin II and reactive oxygen species. Considering this complexity, the aim of our study was to investigate the effects of angiotensin II type-1 receptor blocker - Losartan and superoxide anion scavenger - Tempol, in a combined treatment on acute kidney injury in postischemic hypertensive rats.

机译：缺血性急性肾损伤的特征是肾血管收缩，滤过衰竭，肾小管阻塞，肾小管回漏以及血管紧张素II和活性氧的过量产生。考虑到这种复杂性，我们的研究目的是研究血管紧张素II型1受体阻滞剂-氯沙坦和超氧阴离子清除剂-Tempol在联合治疗缺血性高血压大鼠急性肾损伤中的作用。

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来源
《Acta veterinaria. 》 |2016年第3期| 共14页
作者
Ivanov Milan; Mihailovic-Stanojevic Nevena; Markovic-Lipkovski Jasmina; Jovovic Durdica; Karanovic Danijela; Miloradovic Zoran; Jelica Grujic-Milanovic;
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正文语种 eng
中图分类动物医学（兽医学） ;
关键词
Acute kidney injury; Hypertension; Losartan; Reactive oxygen species; Tempol;

机译：急性肾损伤;高血压;洛沙坦;活性氧;坦泊洛尔;

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专利

1. COMBINED ANGIOTENSIN II TYPE-1 RECEPTOR BLOCKADE AND SUPEROXIDE ANION SCAVENGING AFFECT THE POST-ISCHEMIC KIDNEY IN HYPERTENSIVE RATS [J] . Ivanov Milan, Mihailovic-Stanojevic Nevena, Markovic-Lipkovski Jasmina, Acta veterinaria. . 2016 ,第3期

机译：联合血管紧张素Ⅱ1型受体阻滞剂和过氧化物阴离子消除对高血压大鼠缺血后肾脏的影响
2. Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats. [J] . Cervenka L, Wang CT, Mitchell KD, Hypertension: An Official Journal of the American Heart Association . 1999 ,第1期

机译：Goldblatt高血压大鼠的非闭合肾脏中近端肾小管血管紧张素II水平和对AT1受体阻滞的肾功能反应。
3. Angiotensin II receptor blockade limits kidney injury in two-kidney, one-clip Goldblatt hypertensive rats with special reference to phenotypic changes. [J] . Kobayashi S, Ishida A, Moriya H, The Journal of laboratory and clinical medicine . 1999 ,第2期

机译：血管紧张素II受体阻滞限制了两肾一夹Goldblatt高血压大鼠的肾脏损伤，特别是表型的变化。
4. Angiotensin II Augments Renal Vasoconstriction via AT1 Receptors in L-NAME-induced Hypertensive Rats [C] . Felipe Francisco Rivera-Jardon, Patricia Castro-Moreno, Edgar Saul Figueroa-Guillen, Western Pharmacology Society . 2009

机译：血管紧张素II通过L-Name诱导的高血压大鼠AT1受体增强肾血管收缩
5. The effect of angiotensin II receptor blockade, prior to, during and after a myocardial infarction in rats with and without insulin resistance. [D] . Pourdjabbar, Ali. 2005

机译：在有或没有胰岛素抵抗的大鼠中，在心肌梗塞之前，之中和之后，血管紧张素II受体阻滞的作用。
6. An angiotensin II receptor blocker–calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone [O] . Shokei Kim-Mitsuyama, Hisao Ogawa, Kunihiko Matsui, -1

机译：血管紧张素II受体阻滞剂与钙通道阻滞剂的组合比单独使用大剂量血管紧张素II受体阻滞剂更好地预防老年高危慢性肾脏病高血压患者的心血管事件
7. Combined Angiotensin II Type-1 Receptor Blockade and Superoxide Anion Scavenging Affect the Post-Ischemic Kidney in Hypertensive Rats [O] . Milan Ivanov, Nevena Mihailović-Stanojević, Jasmina Marković-Lipkovski, 2016

机译：联合血管紧张素II型-1受体阻滞和超氧化物阴离子清除影响高血压大鼠的缺血性肾脏

COMBINED ANGIOTENSIN II TYPE-1 RECEPTOR BLOCKADE AND SUPEROXIDE ANION SCAVENGING AFFECT THE POST-ISCHEMIC KIDNEY IN HYPERTENSIVE RATS

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