A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

Dong Jinlan; Ning Wenjing; Mans Daniel J.; Mans Jamie D.

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A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

机译：MALDI-MS和MS / MS快速检测和表征小分子心血管药物的二进制矩阵

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摘要

A mixture of alpha-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (similar to 250-550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.

机译：发现α-氰基-4-羟基氨基酸和1,5-二氨基萘的混合物作为一种新的二元基质，用于通过基质辅助激光解吸/通过基质辅助激光解吸/ 电离质谱（MALDI-MS）和阳性离子模式的MS / MS。

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来源
《Analytical methods》 |2018年第6期|共7页
作者
Dong Jinlan; Ning Wenjing; Mans Daniel J.; Mans Jamie D.;
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作者单位

US FDA Div Pharmaceut Anal Ctr Drug Evaluat &

Res St Louis MO 63110 USA;

US FDA Div Pharmaceut Anal Ctr Drug Evaluat &

Res St Louis MO 63110 USA;

US FDA Div Pharmaceut Anal Ctr Drug Evaluat &

Res St Louis MO 63110 USA;

US FDA Div Pharmaceut Anal Ctr Drug Evaluat &

Res St Louis MO 63110 USA;

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正文语种 eng
中图分类分析化学;
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专利

1. A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS [J] . Jinlan Dong, Wenjing Ning, Daniel J. Mans, Analytical methods . 2018,第6期

机译：通过MALDI-MS和MS / MS快速检测和表征小分子心血管药物的二进制矩阵
2. Optimization of Sample Preparation and Instrumental Parameters for the Rapid Analysis of Drugs of Abuse in Hair samples by MALDI-MS/MS Imaging [J] . Flinders Bryn, Beasley Emma, Verlaan Ricky M., Journal of the American Society for Mass Spectrometry . 2017,第11期

机译：MALDI-MS / MS成像的滥用滥用药物的样品制备和仪器参数的优化
3. Graphene nanosheet mediated MALDI-MS (GN-MALDI-MS) for rapid, in situ detection of intact incipient biofilm on material surfaces [J] . Bo Sgum Wu, Judy Gopal, Pei-Yang Hua, Materials science & engineering . 2016,第SEPa期

机译：石墨烯纳米片介导的MALDI-MS（GN-MALDI-MS）用于快速，原位检测材料表面上完整的初始生物膜
4. Rapid detection, quantification and confirmation of methcathinone-derived designer drugs in equine plasma using LC-MS/MS [C] . Xiaoqing Li, Cornelius Uboh, Lawrence Soma, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用LC-MS / MS在马血浆中快速检测，定量和确认甲肝酮衍生的设计者药物
5. Analysis of hydrocarbon materials by use of nonpolar matrices in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) [D] . Macha, Stephen Francis 2001

机译：在基质辅助激光解吸/电离质谱（MALDI-MS）中使用非极性基质分析烃类物质
6. A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS [O] . Jinlan Dong, Wenjing Ning, Daniel J. Mans, -1

机译：通过MALDI-MS和MS / MS快速检测和表征小分子心血管药物的二进制矩阵
7. Optimization of Sample Preparation and Instrumental Parameters for the Rapid Analysis of Drugs of Abuse in Hair samples by MALDI-MS/MS Imaging [O] . Flinders, Bryn, Beasley, Emma, Verlaan, Ricky M, 2017

机译：通过MALDI-MS / MS成像优化用于快速分析头发样品中滥用药物的样品制备和仪器参数

A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

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