In Vitro and In Silico Studies of Glycyrrhetinic Acid Derivatives as Anti-Filarial Agents

摘要

Background: Lymphatic filariasis is one of the chronic diseases in many parts of the tropics and sub-tropics of the world despite the use of standard drugs diethylcarbamazine and ivermectin because they kill microfilaries and not the adult parasites. Therefore, new leads with activity on adult parasites are highly desirable.