High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial

Park Jung Tak; Lee Hajeong; Kee Youn Kyung; Park Seokwoo; Oh Hyung Jung; Han Seung Hyeok; Joo Kwon Wook; Lim Chun-Soo; Kim Yon Su; Kang Shin-Wook; Yoo Tae-Hyun; Kim Dong Ki

首页> 外文期刊>American Journal of Kidney Diseases: The official journal of the National Kidney Foundation >High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial

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High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial

机译：高剂量与常规剂量连续的静脉血液血液血液腐败和患者和肾脏存活和细胞因子去除在败血症相关的急性肾损伤中：随机对照试验

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Background: Soluble inflammatory mediators are known to exacerbate sepsis-induced acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) has been suggested to play a part in immunomodulation by cytokine removal. However, the effect of continuous venovenous hemodiafiltration (CVVHDF) dose on inflammatory cytokine removal and its influence on patient outcomes are not yet clear.

机译：背景：已知可溶性炎症介质加剧脓毒症诱导的急性肾损伤（AKI）。已经提出连续肾脏替代疗法（CRRT）通过细胞因子去除，在免疫调节中发挥免疫调节部分。然而，连续静脉血液血液血液血氧（CVVHDF）剂量对炎症细胞因子去除的影响及其对患者结果的影响尚不清楚。

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《American Journal of Kidney Diseases: The official journal of the National Kidney Foundation》 |2016年第4期|共10页
作者
Park Jung Tak; Lee Hajeong; Kee Youn Kyung; Park Seokwoo; Oh Hyung Jung; Han Seung Hyeok; Joo Kwon Wook; Lim Chun-Soo; Kim Yon Su; Kang Shin-Wook; Yoo Tae-Hyun; Kim Dong Ki;
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作者单位

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Yonsei Univ Coll Med Dept Internal Med 134 Shinchon Dong Seoul 120752 South Korea;

Seoul Natl Univ Coll Med Dept Internal Med 101 Daehak Ro Seoul 110744 South Korea;

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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Sepsis; acute kidney injury (AKI); sepsis-induced AKI; continuous renal replacement therapy (CRRT); CRRT intensity; continuous venovenous hemodiafiltration (CVVHDF); CVVHDF dose; cytokine removal; interleukins; inflammatory cytokines; immunomodulation; systemic inflammatory response syndrome; randomized controlled trial;

机译：脓毒症;急性肾脏损伤（AKI）;败血症诱导的AKI;连续肾脏替代疗法（CRRT）;CRRT强度;连续的血管血液血液过滤（CVVHDF）;CVVHDF剂量;细胞因子去除;白细胞介素;炎症细胞因子;免疫调节;随机对照试验;

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专利

1. High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial [J] . Park Jung Tak, Lee Hajeong, Kee Youn Kyung, American Journal of Kidney Diseases: The official journal of the National Kidney Foundation . 2016,第4期

机译：大剂量与常规剂量连续静脉血液透析滤过以及脓毒症相关急性肾损伤患者和肾脏存活及细胞因子清除：一项随机对照试验。
2. Citrate anticoagulation versus systemic heparinisation in continuous venovenous hemofiltration in critically ill patients with acute kidney injury: a multi-center randomized clinical trial [J] . Louise Schilder, S Azam Nurmohamed, Frank H Bosch, Critical care : . 2014,第4期

机译：危重症急性肾损伤患者的连续静脉静脉血液滤过中柠檬酸抗凝与全身肝素化：一项多中心随机临床试验
3. Forced fluid removal versus usual care in intensive care patients with high-risk acute kidney injury and severe fluid overload (FFAKI): study protocol for a randomised controlled pilot trial [J] . Rasmus E. Berthelsen, Theis Itenov, Anders Perner, Trials . 2017,第1期

机译：高危急性肾损伤和严重体液超负荷（FFAKI）的重症监护患者中的强制性排泄与常规护理相比：一项随机对照试验研究的研究方案
4. Prediction of Acute Kidney Injury in Cardiac Surgery Patients: Interpretation using Local Interpretable Model-agnostic Explanations [C] . Harry Freitas da Cruz, Frederic Schneider, Matthieu-P. Schapranow International Joint Conference on Biomedical Engineering Systems and Technologies . 2019

机译：心脏手术患者急性肾损伤的预测：利用局部可解释模型 - 不可知解释解释
5. The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial [D] . Tsujita Makoto, 辻田誠 2019

机译：维持高血红蛋白水平对肾移植受者长期肾脏功能的影响：一项随机对照试验
6. The timing of continuous renal replacement therapy initiation in sepsis-associated acute kidney injury in the intensive care unit: the CRTSAKI Study (Continuous RRT Timing in Sepsis-associated AKI in ICU): study protocol for a multicentre randomised controlled trial [O] . Wei-yan Chen, Li-hua Cai, Zhen-hui Zhang, 2021

机译：在重症监护单位中脓毒症相关急性肾损伤连续肾置换治疗开始的时间：CRTSAKI研究（ICU中的败血症相关AKI中的连续RRT时机）：用于多中心随机对照试验的研究方案
7. The timing of continuous renal replacement therapy initiation in sepsis-associated acute kidney injury in the intensive care unit: the CRTSAKI Study (Continuous RRT Timing in Sepsis-associated AKI in ICU): study protocol for a multicentre, randomised controlled trial [O] . Wei-yan Chen, Li-hua Cai, Zhen-hui Zhang, 2021

机译：在重症监护单位中脓毒症相关急性肾损伤连续肾置换治疗开始的时间：CRTSAKI研究（ICU中的败血症相关AKI中的连续RRT时机）：用于多中心，随机对照试验的研究方案
8. Continuous Venovenous Hemofiltration in Severely Burned Patients with Acute Kidney Injury: A Cohort Study. [R] . Chung, K. K., Lundy, J. B., Matson, J. R., 2009

机译：严重烧伤急性肾损伤患者的持续静脉血液滤过：队列研究。

High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial

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